Emergency total ECLS vs standard ACLS with bailout ECMO for OHCA survival

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized interventional study enrolling adults 18-75 with witnessed OHCA, bystander CPR, shockable rhythm, multiple defibrillations, and transport time under 30 minutes. Participants are randomized 1:1 to receive emergency total ECLS or standard ACLS with bailout ECMO, with stratification by site. All patients receive emergency coronary revascularization, intensive care, and up to 180 days of follow-up. The trial aims to determine if earlier, full ECLS improves survival with favorable neurological outcome compared with the staged approach. Informed consent is waived due to emergency research conditions in the ED setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. adults aged 18-75 years old
2. witnessed cardiac arrest with bystander CPR
3. initial shockable rhythm as ventricular fibrillation or pulseless ventricular tachycardia ( VF/pVT )
4. repeated defibrillation shocks ( more than 2 ) by external defibrillator
5. estimated transportation time from 119 call to arrival at emergency service less than 30 minutes.

Exclusion Criteria:

1. age less than 18 years or more than 75 years old
2. non-shockable initial rhythm, i.e. pulseless electrical activity or asystole
3. acute aortic dissection
4. acute massive pulmonary embolism
5. intracerebral hemorrhage
6. major trauma due to blunt, penetrating or burn injury
7. severe peripheral artery occlusion disease
8. known pregnancy
9. suicide, illicit drug overdose or intoxication
10. known pre-arrest modified Rankin score ( mRS ) more than 3 or cerebral performance category scale ( CPC ) more than 2
11. severe concomitant malignancy with expected life expectancy less than 1 year
12. signed and effective do-not-resuscitation ( DNR ) order
13. absolute contraindications to emergency coronary angiography, including known anaphylactic reaction to angiographic contrast media, acute gastrointestinal bleeding or internal bleeding.

Where it's running

• Shuang Ho Hospital
  New Taipei, Taiwan, Taiwan Recruiting
• Shuang Ho Hospital
  New Taipei, Taiwan, Taiwan Recruiting

Study contacts

• Study coordinator: Jiunn-Lee Lin, MD, PHD
• Email: jiunnleelin@gmail.com
• Phone: +886-66202589

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.