Prehospital femoral arterial access to monitor blood pressure during OHCA

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The FEMART-1 Pilot Study explores the feasibility, safety, and timing of prehospital femoral arterial access for invasive pressure monitoring in adults with non-traumatic OHCA. It includes patients with ongoing resuscitation or those who have ROSC, to support continuous hemodynamic management and vasopressor titration. Using ultrasound-guided femoral arterial sheath placement, the study aims to improve perfusion assessment and potentially reduce hypotensive episodes during transport to cardiac arrest centers. This is a feasibility and safety assessment conducted in Prague, involving EMS teams and regional collaborators. The approach could inform whether prehospital arterial monitoring improves outcomes and guides next steps in prehospital cardiac arrest care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\* Non-traumatic out-of-hospital cardiac arrest (OHCA).

Patients meeting criteria for one of the following clinical scenarios:

Group A - ECPR-like group:

* Refractory cardiac arrest, including cardiac arrest occurring in the presence of the EMS crew.
* Age 18-70 years.
* Effective bystander cardiopulmonary resuscitation.
* Initial rhythm of ventricular fibrillation (VF), pulseless ventricular tachycardia (pVT), or pulseless electrical activity (PEA).

Group B - post-ROSC group:

* Return of spontaneous circulation (ROSC) after non-traumatic OHCA.
* Age 18-70 years.

Exclusion Criteria:

* Trauma as the probable primary cause of cardiac arrest.
* Known severe comorbidity, including:

  * terminal stage of incurable disease (advanced malignancy, advanced dementia, terminal pulmonary disease, terminal heart failure, or palliative care status),
  * established do-not-resuscitate (DNR) status,
  * severe pre-existing neurological disability (CPC 3 or CPC 4),
  * known severe peripheral arterial disease or known occlusion of lower limb arteries,
  * suspected pulmonary embolism with indication for thrombolytic therapy,
  * known severe hematological disease associated with severe thrombocytopenia,
  * morbid obesity.
* Known or suspected pregnancy.

Where it's running

• EMS Prague
  Prague, Czechia Recruiting

Study contacts

• Principal investigator: Jan Spicak, MD — Prague Emergency Medical Services
• Study coordinator: Jan Spicak, MD
• Email: jan.spicak@zzshmp.cz
• Phone: 00420776155836

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.