EIT-guided Ventilation Strategy in ARDS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter randomized trial compares an individualized ventilation approach guided by bedside electrical impedance tomography (EIT) to conventional lung-protective ventilation in adults with ARDS. The EIT-guided strategy includes tailoring PEEP and prone positioning based on real-time lung aeration patterns. Participants are followed to assess 28-day mortality and other clinical outcomes. The study is led by Peking Union Medical College Hospital and conducts its work at a major Beijing institution. Eligible patients must have ARDS on mechanical ventilation with onset within 1 week and meet standard diagnostic criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with ARDS receiving mechanical ventilation who meet the following diagnostic criteria:

  1. Triggered by acute risk factors such as pneumonia, non-pulmonary infection, trauma, transfusion, aspiration, or shock. Pulmonary edema is not entirely or predominantly attributable to cardiogenic causes or fluid overload, and hypoxemia/gas exchange impairment is not mainly due to atelectasis. However, ARDS can be diagnosed in the presence of these conditions if predisposing risk factors exist.
  2. Acute onset or worsening of hypoxemic respiratory failure within 1 week of the identified risk factor or onset of new or worsening respiratory symptoms.
  3. Bilateral opacities on chest radiograph or CT, or bilateral B-lines and/or consolidation on ultrasound, not fully explained by effusion, atelectasis, or nodules/masses.
  4. PaO₂/FiO₂ ≤ 300 mm Hg or SpO₂/FiO₂ ≤ 315 (if SpO₂ ≤ 97%).
* ARDS onset within 1 week.
* Mechanical ventilation ≤ 72 hours.

Exclusion Criteria:

* Age \< 18 years.
* Pregnancy.
* Contraindications to EIT application (e.g., local skin lesions, cardiac pacemaker).
* Contraindications to prone positioning (e.g., increased intracranial pressure, intra-abdominal hypertension, spinal fractures).
* Evidence of barotrauma such as pneumothorax, mediastinal emphysema, or subcutaneous emphysema.
* End-stage disease.
* Informed consent not signed by legal guardians or family.

Where it's running

• Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Huaiwu He, MD
• Email: tjmuhhw@163.com
• Phone: 86-010-69152300

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pulse Wave vs Saline Bolus EIT to measure lung perfusion in ARDS

  This study tests whether pulse wave EIT or saline bolus EIT can best show lung blood flow in ARDS patients on mechanical ventilation.

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• Biorepository and endotyping study for ARDS patients

  This observational study tests whether creating a centralized ARDS biorepository and data set can help develop endotype and treatment-prediction tools for adults with ARDS.

  Recruiting Prenosis, Inc. · Urbana, Illinois · NCT07675265

• BAL balance: ARDS through lung lavage and imaging to find different ARDS types

  This study tests how bronchoalveolar lavage fluid and chest CT imaging can reveal different ARDS subtypes in adults with ARDS or severe pneumonia in the ICU.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT07633366

• Titrating PEEP in ARDS: Manual chest compression vs. electrical impedance tomography

  In adults with ARDS on mechanical ventilation, the study tests whether a simple manual chest compression method can set the right PEEP as well as electrical impedance tomography (EIT).

  Recruiting at 2 sites Centre Hospitalier Saint Joseph Saint Luc de Lyon · Créteil and 1 other locations · NCT07623590

• Individualized PEEP Titration in ARDS Based on Lung Recruitment Potential

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  Recruiting Hospital Dr. Franco Ravera Zunino · Rancagua, Región del Libertador General Bernardo O’Higgins · NCT07603310

• Single-dose inhaled rh-KGF-2 for ARDS in adults

  This trial tests whether a single inhaled dose of rh-KGF-2 helps adults with ARDS who are on ventilators, using three dose levels to see which is safest and potentially most effective.

  Recruiting Early Phase 1 Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07558538

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.