Titrating PEEP in ARDS: Manual chest compression vs. electrical impedance tomography
Official title: Titration of Positive End-expiratory Pressure: Comparison Between Manual Thoracic or Abdominal Compression and Electrical Impedance Tomography
Run by Centre Hospitalier Saint Joseph Saint Luc de Lyon · NCT07623590 · Data updated 2026-11-12
In adults with ARDS on mechanical ventilation, the study tests whether a simple manual chest compression method can set the right PEEP as well as electrical impedance tomography (EIT).
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Centre Hospitalier Saint Joseph Saint Luc de Lyon Academic / other |
| Locations | 2 sites (Créteil and 1 other locations) |
| Status | Recruiting |
| Started | April 7, 2025 |
| Main results expected | May 5, 2027 |
| Study ends | May 5, 2027 |
| Registry record updated | June 3, 2026 |
| Trial ID | NCT07623590 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with moderate to severe ARDS on mechanical ventilation, under sedation with neuromuscular blockade, and who can provide informed consent.
✕Probably not a fit
Patients with conditions that preclude manual thoracic compression or where PEEP titration by EIT is unsuitable may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares two methods for titrating positive end-expiratory pressure (PEEP) in adults with moderate to severe ARDS. Each participant undergoes PEEP titration using both techniques in random order while on ventilation and sedation. The trial aims to determine if the low-cost manual chest compression approach can match the PEEP level identified by EIT, potentially guiding ventilator settings with a simple bedside method. Participants are followed for 28 days, with safety and feasibility assessments. The study addresses a practical question about personalized ventilation in ARDS and could influence resource utilization in ICUs.
Why it matters
Potential benefit: If successful, patients could receive individualized PEEP settings using a simple, low-cost technique instead of requiring specialized imaging.
How similar studies have gone: Previous work has explored noninvasive techniques for PEEP optimization, but direct equivalence to EIT-based titration with a simple manual method is novel or limited in scope.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Moderate to severe ARDS according to the Berlin criteria * Patient receiving sedation and continuous curarization * Free and informed consent from the patient or their loved one Exclusion Criteria: * ECMO * Pneumothorax * Chest trauma in the last 3 months * Uncontrolled shock (noradrenaline \> 5 mg/h) * Pregnant or breastfeeding woman * Protected adult within the meaning of the law * Lack of social security * Patient under AME
Where it's running
-
GHU Henri Mondor
Créteil, France Recruiting -
Hôpital Saint Joseph Saint Luc
Lyon, France Recruiting
Study contacts
- Study coordinator: Emmanuel Vivier, MD
- Email: evivier@saintjosephsaintluc.fr
- Phone: +33(0)478618209
Similar studies
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This pilot study tests two personalized PEEP strategies in adults with ARDS to see which approach better supports breathing mechanics by using a recruitment potential measure.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.