BAL balance: ARDS through lung lavage and imaging to find different ARDS types
Official title: Check the BALance: ARDS Deconvolution by Bronchoalveolar Lavage Multiomics Profiling and Radiomics
Run by Medical University of Vienna · NCT07633366 · Data updated 2026-11-12
This study tests how bronchoalveolar lavage fluid and chest CT imaging can reveal different ARDS subtypes in adults with ARDS or severe pneumonia in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 130 (estimated) |
| Sponsor | Medical University of Vienna Academic / other |
| Locations | 1 site (Vienna, State of Vienna) |
| Status | Recruiting |
| Started | July 2026 |
| Main results expected | June 1, 2029 |
| Study ends | June 1, 2030 |
| Registry record updated | July 10, 2026 |
| Trial ID | NCT07633366 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with ARDS or severe CAP requiring mechanical ventilation and ICU care, able to provide consent, and enrolled according to the study group definitions.
✕Probably not a fit
Patients who do not meet ARDS criteria or who do not show distinct biomarker-imaging phenotypes may not derive specific benefits.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study combines analysis of lung fluid and blood with advanced chest CT radiomics to identify ARDS subtypes that may have distinct biological features. By examining microenvironmental and coagulation-related parameters alongside quantitative imaging features, researchers aim to classify ARDS into phenotypes. The study is conducted in adults requiring intensive care, with samples obtained from lavage and blood as part of standard care where possible. Results could illuminate why ARDS progresses differently across patients and guide future targeted approaches. The project is led by the Medical University of Vienna with site collaboration at the General Hospital of Vienna.
Why it matters
Potential benefit: Identifying ARDS subtypes could lead to more personalized management and better targeting of therapies in the ICU.
How similar studies have gone: Other studies using multimodal fluid and radiomic analyses have shown promise in identifying ARDS heterogeneity, though this exact combination is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * male and female * aged 18 years or over * signed consent form * depending on the study group: Confirmed ARDS according to the Berlin criteria (see below, Groups B and D) Confirmed severe CAP requiring mechanical ventilation and intensive care (see below, Groups B and C) Ventilated patients without signs of ARDS (see below, Group E) Exclusion Criteria: \- under 18 years of age
Where it's running
-
General Hospital of Vienna, Medical University of Vienna
Vienna, State of Vienna, Austria Recruiting
Study contacts
- Principal investigator: Riem Gawish, PhD — Medical University of Vienna, Department of Medicine 1
- Study coordinator: Oliver Robak, Prof. PD Dr.
- Email: oliver.robak@meduniwien.ac.at
- Phone: +43 1 40400 44920
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Pulse Wave vs Saline Bolus EIT to measure lung perfusion in ARDS
This study tests whether pulse wave EIT or saline bolus EIT can best show lung blood flow in ARDS patients on mechanical ventilation.
-
Biorepository and endotyping study for ARDS patients
This observational study tests whether creating a centralized ARDS biorepository and data set can help develop endotype and treatment-prediction tools for adults with ARDS.
-
Titrating PEEP in ARDS: Manual chest compression vs. electrical impedance tomography
In adults with ARDS on mechanical ventilation, the study tests whether a simple manual chest compression method can set the right PEEP as well as electrical impedance tomography (EIT).
-
Individualized PEEP Titration in ARDS Based on Lung Recruitment Potential
This pilot study tests two personalized PEEP strategies in adults with ARDS to see which approach better supports breathing mechanics by using a recruitment potential measure.
-
Single-dose inhaled rh-KGF-2 for ARDS in adults
This trial tests whether a single inhaled dose of rh-KGF-2 helps adults with ARDS who are on ventilators, using three dose levels to see which is safest and potentially most effective.
-
HT31-1 for ARDS: a first-in-human test of a monoclonal antibody
This early study tests whether HT31-1, a monoclonal antibody, is safe and how it behaves in the body in healthy adults, with a plan to move into ARDS patients later.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.