EIT-guided PEEP for ARDS patients with higher lung recruitability

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares PEEP set using bedside electrical impedance tomography (EIT) with standard FiO2-PEEP table settings in mechanically ventilated adults with moderate-to-severe ARDS and higher recruitability. Patients eligible are adults within 72 hours of ARDS diagnosis, with a PaO2/FiO2 ≤200 and an RI ratio >0.5 measured within 24 hours. The EIT-guided approach individualizes PEEP based on regional ventilation distribution to try to improve lung recruitment while limiting overdistention. Clinical outcomes, including markers of oxygenation and ventilator-related complications, are compared between groups at participating ICUs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age≥18 years
2. Moderate-to-severe ARDS, defined by the ARDS Definition Task Force in the Berlin definition (partial pressure of arterial oxygen \[PaO2\]:FiO2 ratio ≤200 mmHg with a PEEP ≥5 cmH2O)
3. Diagnosis of ARDS less than 72 hours

Exclusion Criteria:

1. Expected to be mechanically ventilated for less than 48 hours
2. Severe chronic respiratory diseases requiring long-term home oxygen therapy or noninvasive MV
3. Undrained pneumothorax or subcutaneous emphysema
4. Contraindication to the use of EIT (pacemaker, automatic implantable cardioverter defibrillator, and implantable pumps)
5. Severe neuromuscular disease
6. Hemodynamic instability
7. Contraindications to hypercapnia, such as intracranial hypertension or acute coronary syndrome
8. Severe other organs dysfunction with a low expected survival (7 days) or palliative care
9. Severe liver disease (Child-Pugh Score ≥10)
10. Pregnancy
11. Refusal to sign the informed consent

Where it's running

• Department of Critical Care Medicine, Zhongshan Hospital of Fudan University
  Shanghai, China Mainland, China Recruiting
• Zhongda Hospital, School of Medicine, Southeast University
  Nanjing, Jiangsu, China Recruiting
• Second Hospital of Anhui Medical University
  Hefei, Anhui, China Not yet recruiting
• Department of Critical Care Medicine, Renji Hospital
  Shanghai, China Mainland, China Not yet recruiting
• The First Affiliated Hospital of Guangzhou Medical University
  Guangzhou, Guangdong, China Not yet recruiting
• Zhengzhou Central Hospital Affiliated to Zhengzhou University
  Zhengzhou, Henan, China Not yet recruiting

Study contacts

• Study coordinator: yuan xue yan, MD, MD
• Email: 18826401594@163.com
• Phone: +86 83262550

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pulse Wave vs Saline Bolus EIT to measure lung perfusion in ARDS

  This study tests whether pulse wave EIT or saline bolus EIT can best show lung blood flow in ARDS patients on mechanical ventilation.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07908368

• Biorepository and endotyping study for ARDS patients

  This observational study tests whether creating a centralized ARDS biorepository and data set can help develop endotype and treatment-prediction tools for adults with ARDS.

  Recruiting Prenosis, Inc. · Urbana, Illinois · NCT07675265

• BAL balance: ARDS through lung lavage and imaging to find different ARDS types

  This study tests how bronchoalveolar lavage fluid and chest CT imaging can reveal different ARDS subtypes in adults with ARDS or severe pneumonia in the ICU.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT07633366

• Titrating PEEP in ARDS: Manual chest compression vs. electrical impedance tomography

  In adults with ARDS on mechanical ventilation, the study tests whether a simple manual chest compression method can set the right PEEP as well as electrical impedance tomography (EIT).

  Recruiting at 2 sites Centre Hospitalier Saint Joseph Saint Luc de Lyon · Créteil and 1 other locations · NCT07623590

• Individualized PEEP Titration in ARDS Based on Lung Recruitment Potential

  This pilot study tests two personalized PEEP strategies in adults with ARDS to see which approach better supports breathing mechanics by using a recruitment potential measure.

  Recruiting Hospital Dr. Franco Ravera Zunino · Rancagua, Región del Libertador General Bernardo O’Higgins · NCT07603310

• Single-dose inhaled rh-KGF-2 for ARDS in adults

  This trial tests whether a single inhaled dose of rh-KGF-2 helps adults with ARDS who are on ventilators, using three dose levels to see which is safest and potentially most effective.

  Recruiting Early Phase 1 Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07558538

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.