Effects of Preoperative Sleep Problems on Anesthesia Depth and Recovery in Noncardiac Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center prospective cohort study compares perioperative EEG parameters between patients with preoperative sleep disorders and those without. It uses continuous EEG data to examine anesthesia depth, recovery during emergence, and EEG fluctuations in the PACU. Primary outcomes include sleep and sleep architecture metrics from pre- and post-operative polysomnography, assessed on the night after surgery and on postoperative day 1. The aim is to clarify how preoperative sleep issues relate to emergence quality and cerebral protection during anesthesia. Subjects are adults 18–65 undergoing elective noncardiac surgery with ASA I–III, and without major comorbidities affecting CNS function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. \- Aged 18 to 65 years, with American Society of Anesthesiologists (ASA) physical status classification Ⅰ-Ⅲ;
2. Elective non-cardiac surgery with an expected operative duration longer than 2 hours;
3. Preoperative Mini-Mental State Examination (MMSE) score ≥ 24;
4. Completion of the Pittsburgh Sleep Quality Index (PSQI) assessment 1 day before surgery;
5. Absence of severe cardiac, hepatic, renal or cerebral diseases, and no history of psychiatric or neurological disorders;
6. Voluntary provision of written informed consent.

Exclusion Criteria:

1. Preoperative severe cognitive dysfunction, history of traumatic brain injury or stroke;
2. Long-term regular use of sedative-hypnotics, antidepressants or antipsychotics;
3. Intraoperative massive hemorrhage, cardiac arrest, or severe hypoxemia (SpO₂ \< 90% lasting for more than 5 minutes);
4. Inability to cooperate with EEG monitoring or scale evaluation;
5. Pregnancy or breastfeeding status.

Drop-out Criteria :

1. Cancellation of scheduled surgery/anesthesia or postoperative admission to the intensive care unit (ICU);
2. Patient withdrawal of study participation;
3. Intraoperative massive hemorrhage, cardiac arrest, or severe hypoxemia (SpO₂ \< 90% lasting for more than 5 minutes);
4. Development of severe postoperative complications;
5. Incomplete data collection or voluntary trial withdrawal.

Where it's running

• General hospital of Ningxia medical university
  Yinchuan, Ningxia, China Recruiting

Study contacts

• Study coordinator: NA Zhao, Doctoral Candidate
• Email: 18995096494@163.com
• Phone: 86-951-674-3252

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.