Ciprofol vs Propofol in elderly adults having non‑intubated anesthesia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized phase 4 trial, elderly participants (65–80 years, ASA I–III) receiving non‑intubated general anesthesia for gastrointestinal endoscopy will be given either ciprofol or propofol at a rate of 10 mL/min during induction. Sedation depth will be monitored with MOAA/S, while hemodynamic and respiratory function are assessed to compare the two drugs. The study aims to characterize safety and physiologic effects of the two anesthetic agents in this population. Eligible participants are adults 65–80 without major comorbidities or contraindications to the study drugs. Lead sponsor is the General Hospital of Ningxia Medical University, with sites in Yinchuan, Ningxia.

Why it matters

Who can join: the full rules

Inclusion Criteria

1. Elderly patients scheduled to undergo gastrointestinal endoscopy;
2. Aged 65-80 years;
3. American Society of Anesthesiologists (ASA) status of Ⅰ-Ⅲ; Exclusion Criteria

(1)Declined to participate in the study; (2)Had known allergies or contraindications to benzodiazepines, ciprofol, propofol, or related compounds; (3)Had a history of alcohol abuse or dependence on sedative-hypnotics drugs; (4)Severe cardiovascular diseases, including uncontrolled hypertension(SBP ≥160 mmHg or DBP ≥100 mmHg despite medical treatment) or hypotension (SBP ≤90 mmHg or DBP ≤60 mmHg), resting bradycardia (heart rate \< 45 bpm), severe arrhythmia, heart failure, Adams-Stokes syndrome, unstable angina, myocardial infarction within the past 6 months, third-degree atrioventricular block, and QT interval ≥ 450 ms; (5)Severe respiratory diseases, including respiratory insufficiency and chronic obstructive pulmonary disease(COPD), bronchospasm requiring treatment within the previous 3 months, acute respiratory infection accompanied by fever, wheezing, pulmonary rales or cough within the past week, predicted difficult airway(Mallampati grade Ⅳ), and baseline hypoxemia (SpO₂ \< 90%); (6)Liver, kidney, blood system, nervous system, metabolic system or mental diseases with significant clinical significance; (7)Severe gastrointestinal diseases such as gastric retention and persistent gastrointestinal bleeding; (8)Demonstrated uncooperative behavior or impaired communication ability.

Where it's running

• Cardiovascular and Cerebrovascular Disease Hospital, General Hospital of Ningxia Medical University
  Yinchuan, Ningxia, China Recruiting

Study contacts

• Study coordinator: Hanxiang Ma Ma, master
• Email: mahanxiang@hotmail.com
• Phone: 13519591508

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.