Effects of isocapnic respiratory endurance training in healthy adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Healthy adults who regularly train at high levels will perform 5 weeks of voluntary isocapnic hyperpnea training with the BreathWayBetter device or a sham version. The study will measure changes in the intensity and unpleasantness of dyspnea during exercise, as well as peak oxygen uptake (VO2peak) from pre- to post-training. Researchers will also explore how changes in performance relate to changes in perceived breathlessness. The trial aims to help tailor respiratory muscle training for athletes and could inform broader use in clinical populations if effective.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-55 years of age (inclusive)
* Male or Female (biological sex)
* Body mass index greater than 18 or less than 30 kg/m2
* Normal pulmonary function: FEV1/FVC \> 0.70 and FEV1 ≥ 80%
* Able to read and understand English
* Regularly trains and/or competes at a regional, national, or international level as a road cyclist or triathlete
* Access to a device with the capability to download the Isocapnic app (Apple IOS or Google Play/Android) or the ability to use the Web Based application.

Exclusion Criteria:

* Currently smoke, vape, or use cannabis, or have a history of frequent smoking, vaping or cannabis use
* History of, or current symptoms of cardiopulmonary (i.e., lung and/or heart) disease (excluding controlled asthma)
* Heart problem; a serious infection within the body; a neuromuscular (nerve to muscle) or musculoskeletal (muscle, ligament and/or bone) disorder; or other health problem that will be made worse with exercise testing
* Contraindications to exercise testing defined as anything that would prevent exercise under proper and safe conditions (e.g. a problem with the heart or lungs, muscle or bone injury, a serious infection)
* Currently pregnant
* Required to read and understand English due to the nature of the consent form and study materials, including questionnaires and training instructions, which are only available in English.

Where it's running

• St. Paul's Hospital
  Vancouver, British Columbia, Canada Recruiting

Study contacts

• Principal investigator: Jordan Guenette, PhD — University of British Columbia
• Study coordinator: Olivia Ferguson, MSc
• Email: Olivia.Ferguson@hli.ubc.ca
• Phone: 604-806-8835

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.