Effects of different rest times between sets on muscle damage after flywheel exercise in untrained men

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, parallel-group trial compares acute responses to a single lower-limb flywheel workout using three inter-set rest intervals (1, 2, or 3 minutes) in previously untrained men. All participants perform the same exercises (squat, Romanian deadlift, knee extension, and knee flexion) with identical volume and load, with the only difference being the rest duration between sets. Primary outcome is change in knee extensor maximal voluntary isometric contraction 48 hours post-exercise; secondary outcomes include mechanical performance during the session, jump performance, soreness, pain thresholds, range of motion, muscle thickness and echo intensity by ultrasound, perceived exertion and recovery, and blood markers (creatine kinase and lactate dehydrogenase). Participants attend seven lab visits for screening, familiarization, the exercise session, and follow-up assessments at 48 and 96 hours, with blood samples collected before and 72 hours after exercise. The trial is conducted at Federal University of Viçosa, with the lead sponsor being the institution and no collaborators listed.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18 and 40 years;
* Apparently healthy and clinically able to perform physical exercise;
* No participation in structured resistance training during the previous 6 months;
* Agreement to comply with all study visits and procedures;
* Signed informed consent form.

Exclusion Criteria:

* History of lower-limb musculoskeletal injury or surgery that may impair performance or safety during the proposed exercise protocol;
* Current pain, injury, or functional limitation in the lower limbs;
* Use of ergogenic aids that may affect physical performance or muscle recovery;
* Use of analgesic or anti-inflammatory medication during the study period;
* Failure to attend the scheduled visits required for the primary outcome assessment.

Where it's running

• Federal University of Viçosa
  Viçosa, Minas Gerais, Brazil Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.