Effects of ketones on heart recovery after intense exercise

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research evaluates how prolonged and intense exercise impacts heart muscle inflammation and recovery. Participants, who are healthy recreational cyclists, will cycle for three hours, with two hours at an intense pace, while their heart function is monitored. The study aims to determine if exogenous ketones can influence the occurrence and recovery of cardiac abnormalities following intense exercise. Advanced imaging techniques will be used to assess myocardial edema and cardiac function before, immediately after, and 20-24 hours post-exercise.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* healthy recreational male and female cyclists between 18 and 50 years old, who have signed an informed consent form.
* Participants will be included if they achieve a VO2-max/kg value above P90, corrected for age and sex, based on the reference value by E. Van der Steeg et al.

Exclusion Criteria:

* Cardiovascular, metabolic, or respiratory diseases
* Participants with cardiovascular risk factors
* Contraindications for maximum exercise
* Contraindications for MRI.

Where it's running

• Jessa Hospital
  Hasselt, Limburg, Belgium Recruiting

Study contacts

• Study coordinator: Benjamin Peters, MD
• Email: benjamin.peters@jessazh.be
• Phone: +32 11 33 55 55

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.