Clinical trial Recruiting at 1 site Interventional Ages 18 to 30

Acute Cryotherapy on Musculoskeletal Function

Official title: Effects of Acute Cryotherapy on Musculoskeletal Function and Biomarkers for Inflammation, Oxidative Stress, and Muscle Damage

Run by University of Texas, El Paso · NCT07211412 · Data updated 2026-11-12

This study tests whether applying a daily cold-pack after eccentric exercise helps reduce muscle damage and improve function in healthy people.

Quick facts

Study typeInterventional
Ages18 Years to 30 Years
SexAll
Enrollment60 (estimated)
SponsorUniversity of Texas, El Paso
Academic / other
Locations1 site (El Paso, Texas)
StatusRecruiting
StartedNovember 15, 2025
Main results expectedDecember 15, 2027
Study endsMay 15, 2028
Registry record updatedOctober 22, 2026
Trial IDNCT07211412 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Healthy adults who are normotensive, non-smokers, and without recent musculoskeletal injury or cardiovascular disease.

Probably not a fit

Individuals with cardiovascular conditions, pregnancy, recent injuries, or other excluded conditions may not benefit and could be at risk.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, double-blind, controlled trial compares three groups: a no-exercise/no-cryotherapy control, an exercise with room-temperature cooling, and an exercise with daily cryotherapy for 15 minutes. Outcomes include functional measures and blood biomarkers collected at multiple time points up to about 11 days after exercise. The study uses a two-way ANOVA to analyze time and group effects on the measured endpoints.

Why it matters

Potential benefit: If successful, cryotherapy after intense exercise could help lessen muscle damage and speed recovery.

How similar studies have gone: Previous work in cryotherapy and acute muscle injury has shown mixed results, making this trial's randomized design important to clarify potential benefits.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* apparently healthy
* normotensive
* non-smokers (all tobacco products including e-cigarettes)

Exclusion Criteria:

* Cardiovascular diseases (including hypertension)
* pregnancy
* any musculoskeletal injury 6 months prior the study

Where it's running

  • The University of Texas at El Paso, Rehabilitation Sciences Complex
    El Paso, Texas, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.