Effects of Ciprofol on Breathing in Patients on Mechanical Ventilation
The Effect of Ciprofol on Breathing Patterns, Respiratory Drive, and Inspiratory Effort in Mechanically Ventilated Patients
This study tests how the sedative Ciprofol affects breathing in patients on mechanical ventilation after surgery to see if it can improve comfort and safety during their care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Capital Medical University Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT06287138 on ClinicalTrials.gov |
What this trial studies
This study investigates how the sedative Ciprofol affects breathing patterns, respiratory drive, and inspiratory effort in patients who are mechanically ventilated. It aims to improve sedation practices by monitoring respiratory indicators rather than relying solely on subjective sedation scoring systems. The study will include patients who have undergone surgery and are receiving invasive mechanical ventilation, focusing on those requiring sedation for comfort and safety. The goal is to enhance lung-protective sedation strategies in critical care settings.
Who should consider this trial
Good fit: Ideal candidates are adults who have undergone surgery, are intubated, and require sedation while being mechanically ventilated.
Not a fit: Patients under 18 years old, those with certain neurological disorders, or individuals with contraindications to the study medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved sedation practices that better preserve respiratory function in critically ill patients.
How similar studies have performed: Other studies have explored sedation effects on respiratory function, but this specific approach using Ciprofol is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The patient received surgery under general anesthesia and admitted into the ICU * The patient has been intubated and is receiving invasively mechanically ventilated with the mode of pressure support (PSV) or continuous positive airway pressure (CPAP) * The patient requires sedative medication targeting RASS -2 to +1 for comfort, safety and to facilitate the delivery of life support measures Exclusion Criteria: * Age \< 18 years * Body mass index (BMI) \<18 or \>30 kg/m2 * Pregnancy or lactation * Brain stem tumors, myasthenia gravis, or neuromuscular diseases * Acute severe neurological disorder and any other condition interfering with RASS assessment * Systolic blood pressure \< 90 mmHg after appropriate intravenous volume replacement and continuous infusions of 2 vasopressors * Heart rate \< 50 beats per minute or second- or third-degree heart block in the absence of a pacemaker * Contraindicate or allergic to any of the study medications * Acute hepatitis or serious hepatic dysfunction (Child-Pugh class C) * Chronic kidney disease with glomerular filtration rate (GFR) \< 60 ml/min/1.73m2 * Alcohol abuse
Where this trial is running
Beijing, Beijing
- Beijing Tiantan Hospital — Beijing, Beijing, China (Recruiting)
Study contacts
- Study coordinator: Jian-Xin Zhou, MD
- Email: zhoujx.cn@icloud.com
- Phone: +8613801183875
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.