Effect of Smoking and Time of Day on Eosinophils in Healthy Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this cross-over/interventional study, researchers compare blood eosinophil counts and surface markers in 20 chronic smokers and 20 never-smokers. Each smoker undergoes two 4-hour sessions between 8 am and 12 pm: one with no smoking between 8 and 12 am and another after smoking 8 cigarettes, with sessions at least four weeks apart. Blood samples are collected at 8 am and 12 pm in both groups, and analyses include flow cytometry of eosinophil surface molecules, lung function tests, exhaled nitric oxide, and serum IgE. The aim is to see how time of day and acute smoking influence eosinophils and related immune markers in otherwise healthy adults without chronic respiratory disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy current smokers
* Age between 18-50 years
* Smoking of at least 8 cigarettes/day

Exclusion Criteria:

* Chronic respiratory diseases
* Any treatment with corticosteroids or other immunosuppressants
* Any acute illness

Where it's running

• University of Rostock
  Rostock, Germany Recruiting

Study contacts

• Study coordinator: Marek Prof. Lommatzsch, Prof.
• Email: marek.lommatzsch@med.uni-rostock.de
• Phone: +49-381-494-7461

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Do Quercefit® or Ubiqsome™ help with aging and metabolic health in adults 50–75?

  This study tests whether Quercefit® or Ubiqsome™ can improve aging markers, blood sugar, and heart health in sedentary adults aged 50–75 compared with a placebo.

  Recruiting Applied Science & Performance Institute · Tampa, Florida · NCT07760506

• NVTIA Ergothioneine for Healthy Aging and Skin Health

  This study tests whether taking NVTIA Ergothioneine daily for 12 weeks helps healthy adults age more gracefully and keeps skin looking and feeling better compared with a placebo.

  Recruiting European Life Science Research Association · Dhaka · NCT07750002

• Miricell supplementation and markers of healthy aging

  This trial tests whether taking Miricell once daily for 12 weeks improves cellular health and brain/metabolic indicators in adults aged 40–70 compared with a placebo.

  Recruiting Nutraland USA, Inc. · Canfield, Ohio · NCT07675200

• Does daily lean beef support brain health in older adults

  In healthy adults aged 65 and up, this study tests whether eating lean beef every day for two weeks can influence brain health markers compared with a non-beef, protein-matched option.

  Recruiting South Dakota State University · Brookings, South Dakota · NCT07623785

• Adaptive computerized training to boost thinking in healthy seniors and those with mild cognitive impairment

  This study tests whether a computer-based training program can improve executive thinking in older adults, including those with mild cognitive impairment, and see if it also helps memory and well-being.

  Recruiting at 2 sites Universidad Antonio de Nebrija · Madrid, Madrid and 1 other locations · NCT07598409

• SHARP: Personalized Health and Behavior Plan to Lower Biological Age in Older Adults

  A 12-month randomized trial tests whether a personalized health and behavior program can lower biological age and improve function in healthy adults over 50.

  Recruiting Sheba Medical Center · Ramat Gan, Tel Aviv · NCT07596576

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.