Eating according to your body's clock

Circadian Based Time-Restricted Eating Paradigm to Improve Cardiometabolic Health and Prevent Disease

This study is testing if eating meals at the right times according to your body's natural clock can help overweight and obese adults improve their health and manage their weight better.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 10 (estimated)
• Ages: 18 Years to 40 Years
• Sex: All
• Sponsor: Oregon Health and Science University (Academic / other)
• Locations: 1 site (Portland, Oregon)
• Trial ID: NCT05628012 on ClinicalTrials.gov

What this trial studies

This study aims to explore how meal timing in relation to individual circadian rhythms affects cardiometabolic health and weight in overweight and obese adults. Participants will engage in a 46-day intervention focusing on circadian-based time-restricted eating, with data collected both in the field and in a laboratory setting. The research seeks to determine if aligning meal times with personal circadian rhythms can lead to improvements in health outcomes and weight management. This approach is novel as it considers the timing of food intake rather than just the quantity or quality of food consumed.

Who should consider this trial

Good fit: Ideal candidates for this study are healthy, overweight or obese individuals with a BMI of 27 or higher.

Not a fit: Patients with cardiovascular diseases, chronic sleep disorders, or those who have worked irregular hours may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could lead to significant improvements in weight management and overall cardiometabolic health for participants.

How similar studies have performed: While there is emerging evidence supporting the importance of meal timing, this specific circadian-based approach is relatively novel and has not been extensively tested in prior studies.

Eligibility criteria

Inclusion Criteria:

1. Healthy, overweight or obese individuals.

Exclusion Criteria:

1. Participants must have a body mass index (BMI) greater than or equal to 27 kilograms per meter squared.
2. No history of drug or alcohol dependency. Must be current non-smokers, and are required to have a history of less than 5 pack years of smoking.
3. No history of working irregular day and night hours, regular night work, or rotating shift work for the 1 year prior to the study. In addition to this, individuals must not have traveled across more than 1 time zone during the 3 months prior to the study.
4. Chronobiologic and sleep disorders.
5. Diseases of the cardiovascular system.
6. Hypertension. Individuals will be allowed to be normotensive (resting systolic blood pressure of \<140/90 mmHg, measured on more than one occasion) or uncomplicated stage 1 hypertension (systolic BP between 140 and 159 mmHg or a diastolic BP between 90 and 99 mmHg).
7. Disorders of the respiratory system.
8. Pre-diabetes/Diabetes. For participants who have a fasting blood glucose level that is greater than or equal to 100 mg/dL, the investigators will measure hemoglobin A1c to exclude for diabetes (HbA1c\>5.7%).
9. Disorders of the kidney and urinary tract.
10. Infectious diseases.
11. Disorders of the gastrointestinal system.
12. Disorders of the immune system.
13. Disorders of the hematopoietic system.
14. Neoplastic diseases.
15. Endocrine and metabolic diseases.
16. Neurologic disorders.
17. Must not be participating in another research study that would influence their safe participation in the study.

Where this trial is running

Portland, Oregon

• Oregon Health and Science University — Portland, Oregon, United States (Recruiting)

Conditions Circadian Rhythm; Cardiometabolic Health; Weight Loss; Cardiovascular Health; Time Restricted Feeding