Tracking changes in physical strength for adults in the ICU
Official title: Assessment of Physical Function in Critically Ill Patients With the Chelsea Critical Care Assessment Tool (CPAX)
Run by Universidade Federal do Rio de Janeiro · NCT07191743 · Data updated 2026-11-12
We will test whether changes in the Chelsea Critical Care Physical Assessment Tool (CPAx) score between ICU admission and discharge can predict outcomes like death and how long adults need mechanical ventilation.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 186 (estimated) |
| Sponsor | Universidade Federal do Rio de Janeiro Academic / other |
| Locations | 1 site (Rio de Janeiro, Rio de Janeiro) |
| Status | Recruiting |
| Started | January 1, 2025 |
| Main results expected | July 1, 2026 |
| Study ends | December 1, 2027 |
| Registry record updated | September 25, 2025 |
| Trial ID | NCT07191743 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (age ≥18) admitted to the Pedro Ernesto University Hospital general ICU with an expected ICU stay of at least 48 hours who can have CPAx recorded within the first 48 hours and at discharge are ideal candidates.
✕Probably not a fit
Patients likely not to benefit include pregnant individuals, patients with preexisting neuromuscular or neurological disorders causing generalized weakness, ICU readmissions, or those with ICU stays under 48 hours or missing CPAx measurements.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, longitudinal observational study at the Pedro Ernesto University Hospital general ICU that follows critically ill adult patients during their ICU stay. Demographic and clinical data (age, sex, admission cause, comorbidities, SOFA, SAPS III, Charlson index) and treatments (invasive/noninvasive ventilation, HFNC, renal replacement therapy, extubation/reintubation) are collected. CPAx assessments are performed at ICU admission and again at ICU discharge to measure functional change. The study analyzes whether variation in CPAx scores predicts clinical outcomes including mortality, duration of mechanical ventilation, and lengths of ICU and hospital stay.
Why it matters
Potential benefit: If successful, the findings could help clinicians identify patients at higher risk of death or prolonged ventilation so they can target rehabilitation and care earlier.
How similar studies have gone: Previous studies have used the CPAx to measure physical function in ICU populations and shown correlations with functional outcomes, but its predictive value for mortality and ventilator duration is still being clarified.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: All adult patients admitted to the Pedro Ernesto University Hospital (HUPE) General ICU over 18 years of age and with an ICU stay greater than or equal to 48 hours will be included. Exclusion Criteria: * Pregnancy * Inability to record the CPAx score within the first 48 hours of ICU admission or on the day of ICU discharge * ICU readmission * Known comorbidities causing generalized weakness, such as neuromuscular or neurological diseases
Where it's running
-
Pedro Ernesto University Hospital
Rio de Janeiro, Rio de Janeiro, Brazil Recruiting
Study contacts
- Study coordinator: Rafaela S Paim
- Email: rafaeladspaim@gmail.com
- Phone: +5521988919158
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.