Del Nido vs Blood Cardioplegia for Heart Muscle Health During CABG

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patients with multi-vessel coronary artery disease undergoing isolated CABG are randomized to receive either Del Nido or blood cardioplegia during surgery. The primary assessment uses cardiac magnetic resonance imaging to measure myocardial viability, edema, fibrosis, and left ventricular function after surgery. CMR provides a noninvasive, highly sensitive view of how well the heart muscle is preserved with each protection strategy. The trial excludes cases needing other cardiac procedures, off-pump CABG, reduced ejection fraction under 30%, and MRI contraindications. LeadCenter is University Hospital Center Zagreb, with Klinički Bolnički Centar Zagreb as lead sponsor.

Why it matters

Who can join: the full rules

Eligibility Criteria:

1\. Patients with multivessel coronary artery disease scheduled for elective coronary artery bypass grafting

Exclusion Criteria:

1. Left ventricular ejection fraction \<30%
2. Associated cardiac procedures
3. Off-pump coronary artery bypass grafting
4. Contraindications for MRI
5. Inability to provide consent

Where it's running

• University Hospital Center Zagreb
  Zagreb, Croatia Recruiting
• University Hospital Center Zagreb
  Zagreb, Croatia Recruiting

Study contacts

• Principal investigator: Hrvoje Gasparovic — Clinical Hospital Centre Zagreb
• Study coordinator: Hrvoje Gasparovic, MD, PhD
• Email: hrvoje.gasparovic@kbc-zagreb.hr
• Phone: +385 1 236 7529

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.