Does ultrasonic or diode laser irrigation after root canal help reduce pain?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares two irrigation activation methods—ultrasonic and diode laser—against conventional needle irrigation in adult patients undergoing root canal treatment. Participants have symptomatic irreversible pulpitis with apical periodontitis and a vital mandibular single-rooted premolar. Pain levels will be tracked postoperatively, and substance P levels may be explored to understand the biological response. The goal is to see if activation techniques can improve patient comfort and inform evidence-based irrigation protocols.

Why it matters

Who can join: the full rules

Inclusion

1. Healthy patients ranging between 18 and 65 years in age .
2. Patients that experienced moderate-to-severe pain (4-10)-represented on a visual analogue scale (VAS).
3. Having a mandibular single rooted premolar tooth with vital pulp.
4. Having the symptoms of symptomatic irreversible pulpitis and apical periodontitis.

Exclusion

1. Patients who were pregnant or lactating.
2. Patients taking analgesic or anti-inflammatory drugs within the least 12 hours.
3. Teeth with calcified root canals, resorptions.
4. Previously root canal treated.
5. severe damage and associated traumatic occlusion.
6. Teeth with open apices.
7. Presence of periodontal pockets \>3 mm in the affected tooth.

Where it's running

• October 6 university
  Giza, Egypt Recruiting

Study contacts

• Study coordinator: Alaa Hani Omaria, Master degree candidate
• Email: Omariaalaa86@gmail.com
• Phone: 00201507070244

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.