Local active vitamin D injections to speed upper canine movement
Official title: Effect Of Local Use Of 1,25 Dihydroxycholecalciferol on Rate of Canine Distillization: A Split Mouth Randomized Control Trial
Run by Foundation University Islamabad · NCT07479290 · Data updated 2026-11-12
This will try injecting active vitamin D near upper canine teeth to see if it speeds their retraction in people having bilateral maxillary first premolar extractions.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 13 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Foundation University Islamabad Academic / other |
| Locations | 1 site (Islamabad, Federal) |
| Status | Recruiting |
| Started | February 20, 2026 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | March 18, 2026 |
| Trial ID | NCT07479290 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with permanent dentition who are Class I or II malocclusion and scheduled for bilateral maxillary first premolar extractions with at least 5 mm of extraction space.
✕Probably not a fit
Patients with craniofacial deformities (for example cleft lip/palate), metabolic bone disease or diabetes, pregnant or lactating women, or those not undergoing the required premolar extractions would not be expected to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This Phase 1 split-mouth randomized controlled trial will enroll 30 patients scheduled for bilateral maxillary first premolar extractions. Each patient's maxillary arch will be randomized by side: the study side will receive injections of 1,25-dihydroxycholecalciferol in DMSO and the control side will receive plain DMSO placebo at extraction, one month, and two months. Canine retraction distance will be measured on dental impressions at each timepoint to compare movement between sides. The approach tests whether local active vitamin D can accelerate tooth movement without systemic administration.
Why it matters
Potential benefit: If successful, this could shorten the time needed for canine retraction during orthodontic treatment and reduce overall treatment duration.
How similar studies have gone: Animal studies and small clinical reports of local biological agents, including active vitamin D, have shown increased bone turnover and accelerated tooth movement, but strong clinical evidence in humans is still limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient with permanent dentition * Angles class 1,class II dental malocclusion, indicated for bilateral maxillary first premolar extraction * minimum 5 of extraction space Exclusion Criteria: * several craniofacial deformities such as cleft lip and palate * history of bone disease such as osteoporosis or diabetes * pregnant and lactating women
Where it's running
-
Foundation University Islamabad
Islamabad, Federal, Pakistan Recruiting
Study contacts
- Principal investigator: Syeda Hareem Bukhari, BDS, Resident Orthodontics — Foundation University Islamabad
- Study coordinator: Dr. Shoaib Rahim, FCPS
- Email: clinicaltrials.fucd@fui.edu.pk
- Phone: 923215097582
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.