Different intracanal medicines for retreatment of lower first molars

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, single-center phase 1 interventional study comparing three intracanal medications used during retreatment of failed lower first molars with periapical lesions. Patients are allocated equally to calcium hydroxide slurry with sodium hypochlorite, calcium silicate, or calcium hydroxide as the intracanal medicament. Outcomes include inflammatory biomarker IL-1β from periapical fluids, radiographic lesion size by CBCT, and patient-reported pain scores over time. Assessments occur after the second visit (two weeks) and up to 12 months post-treatment to evaluate inflammation reduction, lesion healing, and pain trajectories.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age: 21-45 years.
2. Medically free patients. (ASA Class 1)
3. Gender: males and females
4. Patients who are cooperative at operation and in attendance at scheduled follow-up visits.
5. Restorable root canal treated permanent lower first molars with periapical lesions.
6. Small (\<5 mm) or medium periapical lesion size (5-10 mm)

Exclusion Criteria:

1. Patients with a history of allergic reactions to any of the study materials.
2. Teeth that become non-restorable after complete caries excavation.
3. Teeth that have mobility or deep periodontal pockets.
4. Teeth with internal or external resorption.

Where it's running

• Ain Shams University
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Merna Mamdouh Botros Billatos, Msc
• Email: mernabotros@dent.asu.edu.eg
• Phone: 00201201579537

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.