Evaluating the antimicrobial effects of diclofenac sodium in dental treatments
The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament During Root Canal Treatment: A Randomized Clinical Trial
This study tests if diclofenac sodium can effectively reduce bacteria in root canal treatments for people with chronic tooth infections compared to the standard treatment of calcium hydroxide.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Enrollment | 48 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | British University In Egypt Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06207253 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to assess the effectiveness of diclofenac sodium as an intracanal medicament compared to calcium hydroxide in treating chronic apical periodontitis in permanent molar teeth. Participants will be randomly assigned to receive either diclofenac sodium or calcium hydroxide, and the study will measure bacterial reduction through microbiological assessments before and after treatment. The goal is to determine if diclofenac sodium can serve as a viable alternative to traditional treatments in endodontics.
Who should consider this trial
Good fit: Ideal candidates include patients with permanent molars diagnosed with apical periodontitis and a Periapical Index (PAI) score of 2 or higher.
Not a fit: Patients with immature roots, non-restorable teeth, or those with allergies to diclofenac sodium may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new, effective treatment option for patients suffering from chronic apical periodontitis.
How similar studies have performed: While the use of diclofenac sodium in this context is relatively novel, similar studies have explored the antimicrobial properties of various intracanal medications, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with teeth diagnosed with apical periodontitis * Periapical Index (PAI) ≥ 2 * The teeth are restorable Exclusion Criteria: * Teeth with immature roots * Non restorable teeth * Medically compromised patients with systemic complication that would alter the treatment. * Teeth with internal/external root resorption * Patient with an allergy to diclofenac sodium
Where this trial is running
Cairo
- British university in Egypt — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Summer M Elsayed, Bachelor
- Email: pg.summer92140015@bue.edu.eg
- Phone: 01000095124
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.