Dietary fiber effects on breath VOCs in healthy adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This crossover study compares two short-term dietary interventions (high-fiber and low-fiber diets) in healthy adults. Breath samples are collected at baseline and after each dietary period to characterize volatile organic compounds (VOCs) and identify patterns linked to fiber intake. The goal is to determine when VOCs peak after eating and whether a high-fiber diet shifts the breath profile toward fermentation-related metabolites. Results may inform sampling timing and deepen understanding of how fiber fermentation influences breath VOCs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Signed informed consent obtained prior to any study-related procedures.
2. Willingness to refrain from regular consumption of prebiotic or probiotic products, as well as medications known to affect gastrointestinal function, for at least four weeks prior to the study visits.

Exclusion Criteria:

1. History of complicated gastrointestinal surgery.
2. Presence of a gastrointestinal diagnosis or any condition that, in the opinion of the principal investigator, may influence the study outcomes.
3. Current diagnosis of a psychiatric disorder.
4. Systemic use of antibiotics or steroid medications within the past 3 months.
5. Frequent use of NSAIDs (non-steroidal anti-inflammatory drugs) within the 2 months preceding the study visit.
6. Regular consumption of prebiotic or probiotic products within the past 4 weeks.
7. Alcohol or substance abuse.
8. Current smoking or use of nicotine pouches.
9. Frequent use of laxatives, antidiarrheal agents, or anticholinergic medications within the 12 weeks preceding the study visit.
10. Pregnancy or breastfeeding.
11. Respiratory disease or infection.

Where it's running

• Örebro University
  Örebro, Sweden Recruiting

Study contacts

• Study coordinator: Natalie Sundberg PhD Student
• Email: natalie.sundberg@oru.se
• Phone: +46 704670585

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.