Dexamethasone for dengue with warning signs
Official title: Efficacy of Dengue Infection With Warning Signs Treated With Dexamethasone
Run by Chulalongkorn University · NCT05631405 · Data updated 2026-11-12
This trial will test whether dexamethasone helps people with severe dengue who have warning signs.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 7 Years to 99 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Chulalongkorn University Academic / other |
| Locations | 2 sites (Bangkok and 1 other locations) |
| Status | Recruiting |
| Started | October 16, 2022 |
| Main results expected | November 1, 2026 |
| Study ends | December 31, 2027 |
| Registry record updated | June 16, 2026 |
| Trial ID | NCT05631405 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people with laboratory-confirmed dengue who are still febrile and show warning signs or early severe features within 24 hours of severe illness onset, who are not pregnant and have not received steroids in the past week.
✕Probably not a fit
People with dengue without warning signs, those whose severe dengue began more than 24 hours earlier, pregnant patients, or anyone who received steroids within the previous week are unlikely to be eligible or to benefit from this trial.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized, double-blind, placebo-controlled trial comparing dexamethasone to placebo in patients with laboratory-confirmed dengue who remain febrile and have warning signs or early severe features. Participants are randomly assigned to receive dexamethasone or matching placebo and are monitored for shock, bleeding, fluid accumulation, respiratory distress, and organ involvement. Key exclusion criteria include severe dengue for more than 24 hours, pregnancy, and receipt of steroids within the prior week. Clinical course and safety outcomes are followed in the hospital setting at King Chulalongkorn Memorial Hospital in Bangkok.
Why it matters
Potential benefit: If effective, dexamethasone could reduce life-threatening complications like shock, severe bleeding, or organ failure and may shorten hospital stays.
How similar studies have gone: Previous trials of corticosteroids in dengue have been small and produced mixed or inconclusive results, so steroid treatment for dengue remains unproven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Laboratory confirmed Dengue infected patients (Positive NS1 Ag or anti-DENV IgM by Dengue Duo test) * And still in febrile phase (Body temp\>37.5 C) * Shock : Sys\<90mmHg or Narrow PP (\<20mmHg) orTachycardia (pulse\>100/min) with Hematocrit decreased ≥20 % * Fluid accumulation and respiratory distress * Severe bleeding * Severe organ involvement Exclusion Criteria: * Severe dengue\> 24 hrs * Dengue without warning signs * Pregnancy * Patient who receieved any steroid within 1 week
Where it's running
-
Chulalongkorn University
Bangkok, Thailand Recruiting -
King Chulalongkorn Memorial Hospital
Bangkok, Thailand Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.