Hormonal changes after two bariatric surgeries in super-obese people

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial compares two surgical approaches for super morbid obesity to see how they affect gut hormone responses after a mixed meal. It will measure hormones such as GLP-1, GIP, glucagon, and insulin to understand underlying mechanisms of weight loss and glycemic changes. Participants are adults with BMI between 50 and 60 kg/m2 who qualify for bariatric surgery and do not have diabetes or other prohibitive conditions. The study is conducted at King Chulalongkorn Memorial Hospital in Bangkok under lead sponsor Chulalongkorn University. It is an interventional, procedure-based comparison without a specified randomized phase.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with an indication for bariatric surgery
* BMI 50-60 kg/m2
* Patients who are motivated to lose weight but have not achieved successful weight reduction despite optimal medical therapy and exercise under physician supervision

Exclusion Criteria:

* Patients with diabetes mellitus
* Patients with severe comorbid conditions that contraindicate surgery, such as advanced heart disease or chronic kidney failure
* Patients with a history of previous bariatric surgery
* Patients with gastroesophageal reflux disease refractory to medical therapy, large hiatal hernia, or endoscopic findings of reflux esophagitis grade C or D, or Barrett esophagus
* Patients with psychiatric disorders that impair eating behavior control
* Patients with a history of pancreatitis, pancreatic disease, or inflammatory bowel disease
* Patients who have used steroids or GLP-1 receptor agonists within the past 2 months

Where it's running

• King Chulalongkorn Memorial Hospital
  Pathum Wan, Bangkok, Thailand Recruiting

Study contacts

• Principal investigator: Patchaya Boonchaya-anant, M.D. — King Chulalongkorn Memorial Hospital
• Study coordinator: Primploy Greeviroj, M.D., M.Sc.
• Email: primploy.gre@chulahospital.org
• Phone: +66917142555

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.