Blood biomarker cohort for memory disorders in older adults
Official title: Clinical Cohort of Memory Disorders
Run by Yonsei University · NCT07880275 · Data updated 2026-11-12
This observational cohort will collect blood samples and brain imaging data from adults 50+ with memory disorders and a small group of healthy young adults to help find biomarkers.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 19 Years and up |
| Sex | All |
| Enrollment | 1550 (estimated) |
| Sponsor | Yonsei University Academic / other |
| Locations | 1 site (Seoul, Seodamun-gu) |
| Status | Recruiting |
| Started | September 10, 2020 |
| Main results expected | March 1, 2030 |
| Study ends | September 9, 2030 |
| Registry record updated | October 19, 2026 |
| Trial ID | NCT07880275 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 50 years and older with memory disorders who can provide consent; healthy controls aged 19–30 years who can consent.
✕Probably not a fit
Some participants may not have immediate personal benefit; the study focuses on biomarker discovery and may not impact individual care during the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter observational study links banked blood specimens with clinical and imaging data to support biomarker discovery for memory disorders. It plans to enroll about 1,550 participants across three Severance Hospital sites, including 1,500 older adults and 50 healthy controls aged 19–30, over a 10-year period. Data collected include demographics, medical history, cognitive assessments, and available MRI/PET imaging, with blood separated into plasma and buffy coat and stored at -70°C for later analysis. Enrollment uses non-probability sampling with consent, and a family representative may consent for participants with limited decision-making capacity. The study does not specify an intervention and aims to correlate clinical and imaging findings with stored biomarkers to improve understanding of disease progression.
Why it matters
Potential benefit: If successful, this study could help identify blood-based biomarkers that aid earlier diagnosis and tracking of memory disorders.
How similar studies have gone: Biomarker-banking cohorts linked with imaging have shown promise in memory disorders, suggesting this approach has precedent but remains exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria Memory disorder cohort: Adults of either sex aged 50 years or older. Healthy young adult controls: Adults of either sex aged 19-30 years. Participants must consent to participation. For patients with limited consent capacity and MMSE \<15, additional consent from a family representative is obtained. Exclusuion Criteria Memory disorder cohort: Uncontrolled acute or chronic infection, or another life-threatening systemic illness. Healthy young adult controls: 1. Any current self-reported medical, surgical, neurological, or psychiatric condition. 2. Self-reported history of liver, kidney, or heart disease. 3. Daily medication use. 4. Alcohol consumption on the day before blood collection. 5. Severe impact to the head within the past year, including a motor vehicle accident or fall. 6. Loss of consciousness for any reason within the past year.
Where it's running
-
Yonsei University College of Medicine
Seoul, Seodamun-gu, South Korea Recruiting
Study contacts
- Study coordinator: Eosu Kim, Professor
- Email: KIMEOSU@yuhs.ac
- Phone: +82-2-2228-1620
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.