Cutaneous and Mucosal Signs in Children with Neurofibromatosis Type 2
Official title: Multicentre Prospective Observational Study: Resentment of Mucocutaneous Manifestations and the Value of Dermatological Examination in the Early Detection of Type 2 Neurofibromatosis in Children Under 15 Years of Age
Run by Centre Hospitalier Universitaire de Nice · NCT03893643 · Data updated 2026-11-12
This study looks for skin and mucous membrane signs in kids under 15 who have neurofibromatosis type 2 to see if these features can help with early detection when other symptoms are present.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 0 Years to 15 Years |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice) |
| Status | Recruiting |
| Started | January 1, 2019 |
| Main results expected | December 31, 2022 |
| Study ends | June 25, 2027 |
| Registry record updated | June 29, 2026 |
| Trial ID | NCT03893643 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children under 15 years old with a diagnosis of neurofibromatosis type 2.
✕Probably not a fit
Patients without NF2 or with late-diagnosed NF2 may not benefit from these observations.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to document the cutaneous and mucosal manifestations of neurofibromatosis type 2 in children under the age of 15. It analyzes whether these signs could contribute to earlier recognition of the disease alongside other neurological or ophthalmological features. There are no interventions; data collection centers on clinical observations and patient records. The study is led by Centre Hospitalier Universitaire de Nice and conducted at Nice Hospital in France. Eligibility includes being under 15 years old and having a confirmed diagnosis of NF2.
Why it matters
Potential benefit: If successful, the findings could help clinicians recognize NF2 earlier by noting skin and mucosal signs in pediatric patients.
How similar studies have gone: While cutaneous signs have been described in NF2, this pediatric-focused effort to link mucocutaneous manifestations with early detection is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age up to 15 years * diagnosis of neurofibromatosis type 2 Exclusion Criteria: * refusal to participate in the study * informed consent that can not be obtained because of a disability or difficulties with a - language barrier
Where it's running
-
Nice Hospital
Nice, France Recruiting
Study contacts
- Study coordinator: Sophie LEGOUPIL
- Email: sophie.legoupil@hotmail.fr
- Phone: 336 81818020
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.