CT‑XPI: a contrast‑free CT method to map lung perfusion
Official title: Evaluation of Computed Tomography X-ray-Pulsatility Index (CT-XPI)
Run by University of Wisconsin, Madison · NCT07192133 · Data updated 2026-11-12
This trial will test whether a new contrast‑free, high‑frame‑rate CT method (CT‑XPI) can show lung perfusion better than standard CT scans in adults having a clinically indicated CT.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Wisconsin, Madison Academic / other |
| Locations | 1 site (Madison, Wisconsin) |
| Status | Recruiting |
| Started | January 26, 2026 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | June 10, 2026 |
| Trial ID | NCT07192133 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older who can give informed consent and are already scheduled for a clinically indicated CT exam, especially chest imaging, are ideal candidates.
✕Probably not a fit
Pregnant or lactating people, those needing urgent or emergent care, or patients judged by investigators to have conditions that interfere with the protocol are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This Phase 2 interventional study uses prospectively acquired dynamic, high‑frame‑rate chest CT to compute an X‑ray Pulsatility Index and produce maps of lung perfusion without intravenous contrast. Participants who meet eligibility will undergo a roughly 30‑minute chest CT using the dynamic imaging protocol in addition to their clinically indicated imaging. The primary aim is to collect human dynamic CT data to compare the information content of CT‑XPI maps with standard static CT imaging. Safety exclusions include pregnancy, lactation, urgent/emergent care needs, or any condition the investigator judges could interfere with safe participation or data quality.
Why it matters
Potential benefit: If successful, CT‑XPI could give clinicians useful lung perfusion information without contrast agents, potentially reducing contrast exposure and improving diagnostic information.
How similar studies have gone: This contrast‑free, dynamic CT approach is relatively novel with limited prior human data, so comparable clinical success has not been broadly established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Able to sign and date the informed consent form * Will undergo a clinically-indicated CT exam of the head, neck, chest, abdomen, pelvis, or extremities Exclusion Criteria: * Pregnant or lactating * In need of urgent or emergent care * Have any conditions that, in the opinion of the PI or designee, would interfere with the evaluation of the results or constitute a health hazard for the participant
Where it's running
-
University of Wisconsin - Madison
Madison, Wisconsin, United States Recruiting
Study contacts
- Principal investigator: Matthew Smith, MD, PhD — University of Wisconsin, Madison
- Study coordinator: Radiology Studies
- Email: radstudy@uwhealth.org
- Phone: 608-282-8349
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.