Photon-counting CT vs standard HRCT to help diagnose IPF and other ILDs

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study prospectively compares photon-counting CT (PCDCT) to conventional HRCT in people with interstitial lung disease who are being evaluated in a multidisciplinary discussion. It uses non-contrast spectral ultra-high-resolution scans on a dual-source PCDCT to better depict fibrotic features while maintaining low radiation exposure. The goal is to see if PCDCT can improve diagnostic confidence and reduce unclassifiable ILD by more clearly characterizing patterns like reticulation and traction bronchiectasis. Findings will inform whether PCDCT offers a meaningful improvement over HRCT in routine ILD assessment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥ 18 years of age
* Any gender
* Any race
* Signed informed consent
* ILD diagnosis with the need for a multidisciplinary discussion

Exclusion Criteria:

* Patients with acute exacerbation of ILD
* Interstitial abnormalities that could be explained by causes different than ILD (e.g.: heart failure; viral)

Where it's running

• Humanitas Research Hospital
  Rozzano, Italy, Italy Recruiting

Study contacts

• Principal investigator: Francesco Amati, MD — Humanitas Research Hospital IRCCS, Rozzano-Milan
• Study coordinator: Francesco Amati, MD
• Email: franesco.amati@hunimed.eu
• Phone: +393282592750

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.