CTG vs Collagen Matrix for Peri-Implant Soft Tissue Augmentation
Official title: Results of Soft Tissue Grafting Around Implant in the Mandible Molar Area
Run by Hanoi Medical University · NCT07371481 · Data updated 2026-11-12
This study tests whether a collagen matrix can match the results of a connective tissue graft for thickening and shaping peri-implant tissue around mandibular molars.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 46 (estimated) |
| Sponsor | Hanoi Medical University Academic / other |
| Locations | 1 site (Hanoi) |
| Status | Recruiting |
| Started | January 1, 2026 |
| Main results expected | December 2027 |
| Study ends | September 2028 |
| Registry record updated | September 16, 2026 |
| Trial ID | NCT07371481 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 with mandibular molar implants and insufficient peri-implant soft tissue thickness (<2 mm) who are healthy enough for minor oral surgery.
✕Probably not a fit
Individuals with systemic conditions affecting healing, heavy smoking, or prior graft failures at the implant site may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this randomized trial at a single academic center, adults needing a dental implant in the mandibular molar area with thin peri-implant tissue are assigned to receive either an autogenous connective tissue graft or a collagen matrix at implant placement. Outcomes include changes in tissue thickness, width of keratinized tissue, and soft tissue contour over 9 months, assessed by clinical measures and digital imaging, with blinded evaluation. Postoperative healing and adverse events are monitored throughout the follow-up. The goal is to determine if the collagen matrix provides similar clinical results to the connective tissue graft and to assess safety.
Why it matters
Potential benefit: If successful, patients could benefit from a less invasive option that provides comparable soft tissue outcomes to a connective tissue graft.
How similar studies have gone: Previous work in periodontal and implantology contexts has shown mixed results; this study adds direct comparison between CTG and collagen matrix in a defined peri-implant region.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Adults aged 18 to 65 years. Patients requiring dental implant treatment in the mandibular molar region. Presence of insufficient peri-implant soft tissue thickness (\< 2 mm). Adequate general health to undergo minor oral surgery. Ability and willingness to provide written informed consent and comply with study procedures. Exclusion Criteria: Systemic conditions or medications that may impair wound healing. Heavy smoking (more than 10 cigarettes per day). History of allergy or hypersensitivity to collagen-based materials. Previous graft failure or complications at the intended implant site. Loss of three or more adjacent teeth in the study area (excluding third molars).
Where it's running
-
School of Dentistry, Hanoi Medical University
Hanoi, Vietnam Recruiting
Study contacts
- Study coordinator: Phu Manh Nguyen, DDS, MSc
- Email: manhphu@hmu.edu.vn
- Phone: (+84) 2435747005
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.