Comparing IVF outcomes and embryo development between PPOS and GnRH antagonist protocols using time-lapse culture
Official title: IVF Outcomes With Time-Lapse Culture: Comparison Between PPOS and GnRH Antagonist Protocols
Run by Hanoi Medical University · NCT07409493 · Data updated 2026-11-12
This trial tests whether a fixed progestin-primed ovarian stimulation (PPOS) protocol produces similar numbers of mature eggs, good-quality embryos, and clinical outcomes — and whether embryo development patterns differ — compared with a GnRH antagonist protocol in women undergoing IVF with a planned freeze-all strategy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 45 Years |
| Sex | Women only |
| Enrollment | 148 (estimated) |
| Sponsor | Hanoi Medical University Academic / other |
| Locations | 1 site (Hanoi) |
| Status | Recruiting |
| Started | January 21, 2026 |
| Main results expected | June 2028 |
| Study ends | October 2028 |
| Registry record updated | February 13, 2026 |
| Trial ID | NCT07409493 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 20–45 who are indicated for IVF, plan a freeze-all embryo strategy, and are willing to be randomized and attend treatment at the study site are ideal candidates.
✕Probably not a fit
Patients using oocyte donation cycles, those needing a fresh embryo transfer, with recent hormonal treatment, or with significant systemic disease are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this randomized interventional study, 148 women undergoing IVF with a planned freeze-all approach are allocated 1:1 to a fixed PPOS protocol or a GnRH antagonist protocol. Both groups receive controlled ovarian stimulation and oocyte retrieval, while resulting embryos are monitored with time-lapse imaging to capture morphokinetic parameters and derive KIDScore rankings. Primary comparisons include mature oocyte yield, number of good-quality embryos, clinical outcomes after transfer of frozen embryos, and differences in time-lapse morphokinetics between protocols. Statistical analyses will compare group-level outcomes to determine whether the PPOS approach yields comparable laboratory and clinical results and whether morphokinetic patterns differ.
Why it matters
Potential benefit: If successful, the study could offer patients a simpler or alternative stimulation option that yields similar IVF outcomes and improve embryo selection by clarifying morphokinetic differences.
How similar studies have gone: Previous clinical reports have often found PPOS yields comparable oocyte and pregnancy outcomes to antagonist protocols, but combining these comparisons with time-lapse morphokinetic and KIDScore analysis is a less-explored and relatively novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women aged 20-45 years * Indicated for in vitro fertilization (IVF) treatment * Planned freeze-all embryo strategy * Voluntary participation in research. Exclusion Criteria: * Systemic diseases * Use of hormonal medications within 3 months prior to enrollment * Oocyte donation cycles * Unwilling or unable to participate in research
Where it's running
-
Hanoi Obstetrics and Gynecology Hospital
Hanoi, Vietnam Recruiting
Study contacts
- Study coordinator: Thanh Huy Dao, MD
- Email: huythanhdao.hmu@gmail.com
- Phone: +84 971597096
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.