CRP point-of-care testing to guide antibiotic use for adults with respiratory symptoms in eight Jakarta primary care centers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study evaluates the implementation of C-reactive protein (CRP) point-of-care testing in eight primary health care centers in Jakarta to reduce unnecessary antibiotic prescriptions for acute respiratory tract infections (ARTI) without increasing clinical failures by day seven. The study uses a cluster design to compare the CRP-guided approach with standard care, enrolling about 2,544 adults across sites with a target of roughly 318 patients per center. The sample size and analysis account for intra-cluster correlation and a non-inferiority margin, aiming to preserve clinical outcomes while decreasing antibiotic exposure. The investigation builds on prior data from LMICs and seeks to adapt ICC assumptions to the Indonesian primary care context. Leading institutions include the Oxford University Clinical Research Unit Indonesia and collaborating hospitals and universities in Indonesia and Vietnam.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adults aged ≥18 years.
2. Presenting to the PHC site for the first consultation of the current episode of Acute-Respiratory Tract Infections (ARTI).
3. Reporting at least one of the following symptoms or clinical signs within the past 5 days: cough, rhinitis (e.g., sneezing, nasal congestion, or runny nose), pharyngitis (e.g., sore throat), shortness of breath, wheezing, chest pain, abnormal lung sounds on auscultation.

Exclusion Criteria:

1. Presenting with severe illness requiring referral to a higher-level healthcare facility (e.g., hospital).
2. Having known immunosuppression or chronic conditions, including but not limited to: HIV infection; chronic liver disease; history of malignancy; long-term use of systemic corticosteroids or other immunosuppressive therapies, as assessed by the healthcare worker or study team.
3. Having taken antibiotics prior to the visit to the primary health center.

Where it's running

• Cengkareng Public Health Center
  Jakarta, Indonesia Recruiting
• Pulo Gadung Public Health Center
  Jakarta, Indonesia Recruiting
• Jatinegara Public Health Center
  Jakarta, Indonesia Recruiting
• Duren Sawit Public Health Center
  Jakarta, Indonesia Recruiting
• Cakung Public Health Center
  Jakarta, Indonesia Recruiting
• Cilincing Public Health Center
  Jakarta, Indonesia Recruiting

Study contacts

• Principal investigator: Robert Sinto, MD, DPhil — Dr Cipto Mangunkusumo General Hospital
• Study coordinator: Robert Sinto, MD, DPhil
• Email: rsinto@oucru.org
• Phone: +622123599099

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.