Clinical trial Recruiting at 11 sites Observational

Observational study of acute respiratory infections in adults

Official title: Perpetual Observational Study of Acute Respiratory Infections Presenting Via Emergency Rooms and Other Acute Hospital Care Settings

Run by European Clinical Research Alliance for Infectious Diseases (ECRAID) · NCT05814237 · Data updated 2026-11-12

This study looks at how adults with acute respiratory infections are treated in hospitals across Europe to see what works best and improve patient care.

More Respiratory Viral Infection trials

Quick facts

Study typeObservational
SexAll
Enrollment11750 (estimated)
SponsorEuropean Clinical Research Alliance for Infectious Diseases (ECRAID)
Academic / other
Locations27 sites (Antwerp and 26 other locations)
StatusRecruiting
StartedJune 20, 2023
Main results expectedFebruary 28, 2027
Study endsFebruary 28, 2027
Registry record updatedOctober 29, 2026
Trial IDNCT05814237 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 years and older who present to emergency rooms with a clinical suspicion of a new episode of acute respiratory tract infection.

Probably not a fit

Patients who have been transferred from another hospital or those who have been admitted for more than two days at the time of enrollment may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The POS-ARI-ER study is an observational study aimed at characterizing acute respiratory infections (ARIs) in adults presenting to hospitals across Europe. It focuses on the diagnostic and therapeutic practices used in the management of ARIs, as well as the clinical outcomes of patients. The study will collect data on routine diagnostic methods and pharmacological interventions through standardized report forms, providing insights into the etiology of ARIs and the effectiveness of current treatment strategies. By evaluating the implementation of advanced diagnostic technologies, the study seeks to improve patient outcomes and reduce antimicrobial resistance.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnostic and treatment strategies for acute respiratory infections, enhancing patient care and outcomes.

How similar studies have gone: Other studies have shown success in utilizing advanced diagnostic methods for respiratory infections, indicating that this approach has potential for meaningful impact.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Inclusion criterion for Group 1:

* Age ≥ 18 years

Inclusion criterion for Group 2:

* Age \< 18 years
* Clinical suspicion of a new episode of acute respiratory tract infection, with onset in the last 10 days
* Patient presents to an emergency room or secondary care setting
* Informed consent is provided by patient or their legal representative

Exclusion Criteria:

* Patient has been transferred from another hospital
* Patient admitted to hospital for \>2 days at the time of enrolment
* Patient has been previously enrolled in the POS-ARI-ER study

Where it's running

  • Universitair Ziekenhuis Antwerpen
    Antwerp, Belgium
    Recruiting
  • CHU Limoges
    Limoges, France
    Recruiting
  • Noordwest Ziekenhuisgroep
    Alkmaar, Netherlands
    Recruiting
  • Amsterdam UMC
    Amsterdam, Netherlands
    Recruiting
  • Carol Davila University of Medicine and Pharmacy Bucharest
    Bucharest, Romania
    Recruiting
  • General Hospital, Kragujevac
    Kragujevac, Serbia
    Recruiting
Show 21 more locations
  • Hospital General Universitario de Alicante
    Alicante, Spain
    Recruiting
  • Hospital Universitario Vall d'Hebron
    Barcelona, Spain
    Recruiting
  • Hospital Universitario Virgen Macarena
    Seville, Spain
    Recruiting
  • Craigavon Area Hospital
    Craigavon, United Kingdom
    Recruiting
  • South Tyneside and Sunderland NHS Foundation
    Sunderland, United Kingdom
    Recruiting
  • Erasme Hospital
    Brussels, Belgium
    Completed
  • University Hospital for Infectious Diseases, Zagreb
    Zagreb, Croatia
    Completed
  • CHU Grenoble
    Grenoble, France
    Completed
  • CHU Lyon
    Lyon, France
    Completed
  • CHU de Tours
    Tours, France
    Completed
  • General University Hospital of Patras
    Pátrai, Greece
    Completed
  • Azienda Ospedaliera Policlinico di Bari
    Bari, Italy
    Completed
  • Radboud University Medical Center
    Nijmegen, Netherlands
    Completed
  • Agrippa Ionescu Hospital, Carol Davila University of Medicine and Pharmacy Bucharest
    Bucharest, Romania
    Completed
  • Infectious and Tropical Diseases Hospital "Dr. Victor Babes"
    Bucharest, Romania
    Completed
  • Cluj Napoca Infectious Disease Clinical Hospital
    Cluj-Napoca, Romania
    Completed
  • NHS Lothian- Royal Infirmary of Edinburgh and St Johns Hospital
    Edinburgh, United Kingdom
    Completed
  • Gateshead Health NHS Foundation Trust
    Gateshead, United Kingdom
    Completed
  • Liverpool University Hospitals NHS Foundation Trust
    Liverpool, United Kingdom
    Completed
  • Royal Free London NHS Foundation Trust - Royal Free Hospital
    London, United Kingdom
    Completed
  • Sheffield Teaching Hospitals NSH Foundation Trust
    Sheffield, United Kingdom
    Completed

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.