Observational study of acute respiratory infections in adults
Official title: Perpetual Observational Study of Acute Respiratory Infections Presenting Via Emergency Rooms and Other Acute Hospital Care Settings
Run by European Clinical Research Alliance for Infectious Diseases (ECRAID) · NCT05814237 · Data updated 2026-11-12
This study looks at how adults with acute respiratory infections are treated in hospitals across Europe to see what works best and improve patient care.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 11750 (estimated) |
| Sponsor | European Clinical Research Alliance for Infectious Diseases (ECRAID) Academic / other |
| Locations | 27 sites (Antwerp and 26 other locations) |
| Status | Recruiting |
| Started | June 20, 2023 |
| Main results expected | February 28, 2027 |
| Study ends | February 28, 2027 |
| Registry record updated | October 29, 2026 |
| Trial ID | NCT05814237 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 years and older who present to emergency rooms with a clinical suspicion of a new episode of acute respiratory tract infection.
✕Probably not a fit
Patients who have been transferred from another hospital or those who have been admitted for more than two days at the time of enrollment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The POS-ARI-ER study is an observational study aimed at characterizing acute respiratory infections (ARIs) in adults presenting to hospitals across Europe. It focuses on the diagnostic and therapeutic practices used in the management of ARIs, as well as the clinical outcomes of patients. The study will collect data on routine diagnostic methods and pharmacological interventions through standardized report forms, providing insights into the etiology of ARIs and the effectiveness of current treatment strategies. By evaluating the implementation of advanced diagnostic technologies, the study seeks to improve patient outcomes and reduce antimicrobial resistance.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and treatment strategies for acute respiratory infections, enhancing patient care and outcomes.
How similar studies have gone: Other studies have shown success in utilizing advanced diagnostic methods for respiratory infections, indicating that this approach has potential for meaningful impact.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Inclusion criterion for Group 1: * Age ≥ 18 years Inclusion criterion for Group 2: * Age \< 18 years * Clinical suspicion of a new episode of acute respiratory tract infection, with onset in the last 10 days * Patient presents to an emergency room or secondary care setting * Informed consent is provided by patient or their legal representative Exclusion Criteria: * Patient has been transferred from another hospital * Patient admitted to hospital for \>2 days at the time of enrolment * Patient has been previously enrolled in the POS-ARI-ER study
Where it's running
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Universitair Ziekenhuis Antwerpen
Antwerp, Belgium Recruiting -
CHU Limoges
Limoges, France Recruiting -
Noordwest Ziekenhuisgroep
Alkmaar, Netherlands Recruiting -
Amsterdam UMC
Amsterdam, Netherlands Recruiting -
Carol Davila University of Medicine and Pharmacy Bucharest
Bucharest, Romania Recruiting -
General Hospital, Kragujevac
Kragujevac, Serbia Recruiting
Show 21 more locations
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Hospital General Universitario de Alicante
Alicante, Spain Recruiting -
Hospital Universitario Vall d'Hebron
Barcelona, Spain Recruiting -
Hospital Universitario Virgen Macarena
Seville, Spain Recruiting -
Craigavon Area Hospital
Craigavon, United Kingdom Recruiting -
South Tyneside and Sunderland NHS Foundation
Sunderland, United Kingdom Recruiting -
Erasme Hospital
Brussels, Belgium Completed -
University Hospital for Infectious Diseases, Zagreb
Zagreb, Croatia Completed -
CHU Grenoble
Grenoble, France Completed -
CHU Lyon
Lyon, France Completed -
CHU de Tours
Tours, France Completed -
General University Hospital of Patras
Pátrai, Greece Completed -
Azienda Ospedaliera Policlinico di Bari
Bari, Italy Completed -
Radboud University Medical Center
Nijmegen, Netherlands Completed -
Agrippa Ionescu Hospital, Carol Davila University of Medicine and Pharmacy Bucharest
Bucharest, Romania Completed -
Infectious and Tropical Diseases Hospital "Dr. Victor Babes"
Bucharest, Romania Completed -
Cluj Napoca Infectious Disease Clinical Hospital
Cluj-Napoca, Romania Completed -
NHS Lothian- Royal Infirmary of Edinburgh and St Johns Hospital
Edinburgh, United Kingdom Completed -
Gateshead Health NHS Foundation Trust
Gateshead, United Kingdom Completed -
Liverpool University Hospitals NHS Foundation Trust
Liverpool, United Kingdom Completed -
Royal Free London NHS Foundation Trust - Royal Free Hospital
London, United Kingdom Completed -
Sheffield Teaching Hospitals NSH Foundation Trust
Sheffield, United Kingdom Completed
Study contacts
- Study coordinator: Jake Dunning
- Email: pos-ari-er@ndm.ox.ac.uk
- Phone: 01865 612974
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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CRP point-of-care testing to guide antibiotic use for adults with respiratory symptoms in eight Jakarta primary care centers
This trial tests whether using a C-reactive protein point-of-care test can help doctors in Jakarta decide when antibiotics are needed for adults with acute respiratory infections.
-
National guideline program to reduce unnecessary antibiotics for colds and flu-like illnesses in Swiss primary care
This project will test whether training family doctors to use new Swiss guidelines, point-of-care CRP testing, and shared decision-making can reduce unnecessary antibiotic prescriptions for adults with acute respiratory or flu-like illnesses in primary care.
-
Observational study on acute respiratory infections in primary care across Europe
This study looks at how acute respiratory infections are treated in adults and children visiting primary care in Europe to help improve care and support future research.
-
Different doses of Ingavirin Forte capsules for adults with influenza or other acute respiratory infections.
This trial will see if different doses of Ingavirin Forte capsules help adults (18–65) with PCR-confirmed influenza or other acute respiratory viral infections.
-
Efficacy and safety of Raphamin for treating respiratory infections in children
This study is testing if a new medicine called Raphamin can help children aged 3 to 12 with respiratory infections feel better and recover faster.
-
Observational study of severe acute respiratory infections
This study is trying to learn more about severe respiratory infections in hospitalized patients during winter to help prepare for future outbreaks.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.