Crossover vs Accurate Ostial Stenting for Left Main Bifurcation Lesions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study compares accurate ostial stenting with crossover stenting that extends from the left main artery into the daughter vessel for ostial lesions. It aims to generate prospective, methodologically robust data on clinically important outcomes such as major adverse cardiovascular events and need for revascularization. Eligible participants have ostial disease of the LAD or LCx and are undergoing second- or third-generation drug-eluting stent implantation. The analysis will focus on differences in procedural success, residual stenosis, and short- to mid-term clinical endpoints. Current evidence is largely retrospective, and this study seeks to standardize approaches and improve evidence-based decision making for these high-risk lesions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ostial left anterior descending artery or left circumflex artery disease
* Coronary intervention with second or third generation drug-eluting stent

Exclusion Criteria:

* Severe left main disease (≥30%, intravascular ultrasound plaque burden \>50%)
* History of coronary bypass grafting
* Cardiogenic shock
* Left main diameter greater than stent expansion capacity (for crossover group)
* In-stent restenosis
* End-stage liver or kidney disease (cirrhosis, hemodialysis-dependent chronic kidney disease),
* Coronary intervention with bare-metal stent
* Early discontinuation or inappropriate use of DAPT treatment
* Patients lost to follow-up
* Patient life expectancy \<1 year (such as cancer)

Where it's running

• İstanbul Mehmet Akif Ersoy Thoracic And Cardiovascular Surgery Training and Research Hospital
  Istanbul, Turkey (Türkiye) Recruiting
• Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Hospital
  Istanbul, Please Select, Turkey (Türkiye) Active not recruiting

Study contacts

• Study coordinator: Ahmet Güner, MD
• Email: ahmetguner488@gmail.com
• Phone: +90212692200

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.