Connectomic changes after stroke in the middle cerebral artery area

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will use advanced MRI, including diffusion and resting-state scans, to map brain connectivity after acute ischemic stroke in MCA territory. The study applies machine learning and connectomics to understand how disruptions in brain networks relate to motor and cognitive recovery. It is observational in nature, focusing on network-level analyses to improve prognostic insight and potentially tailor rehabilitation strategies. Participants are adults with MCA strokes who have received reperfusion therapy and can undergo sequential MRI scans. The effort emphasizes safe, non-invasive imaging to elucidate patterns of diaschisis and network reorganization over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \> 18 years;
* Diagnosis of acute ischemic stroke with confirmed occlusion of the M1 or more distal MCA territory.
* Received reperfusion therapy via mechanical thrombectomy or IV thrombolytics(Tenecteplase, or Alteplase).
* Presence of a motor deficit on initial clinical exam (e.g., NIHSS \> 0) and on immediate post-intervention exam.
* Patients or health-care proxy must be able to provide informed consent.
* Must be able to undergo sequential MRI at Lenox Hill Hospital, including resting-state fMRI (rs-fMRI) and diffusion MRI (dMRI) for, respectively, functional, and structural connectomic analyses.

Exclusion Criteria:

* Age \< 17 years;
* Large vessel occlusions proximal to M1 (e.g., ICA), completed M1 occlusions.
* Pre-stroke Modified Rankin Scale score ≥ 3
* Known neurodegenerative disease or prior stroke affecting motor pathways.
* Inability to undergo MRI due to cardiac pacemaker, claustrophobia, and metal implants that cannot be removed prior to MRI.
* Pregnancy. Because of potential risk of serial MRI to fetus, women of child-bearing age require a pregnancy test at screening and agree to contraceptive practices during the study.
* Poor image quality or incomplete imaging datasets.

Where it's running

• Lenox Hill Hospital
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Randy D'Amico, MD — Northwell Health Lenox Hill Hospital
• Study coordinator: Tamika Wong, MPH
• Email: twong4@northwell.edu
• Phone: (212) 434-4836

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

  This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.

  Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Leuven and 6 other locations · NCT07924371

• Remote ischemic conditioning for post-stroke insomnia

  A 136-person, randomized study will test whether a non-invasive arm-cuff procedure done twice daily for 90 days can improve sleep after a first ischemic stroke in adults 18–80.

  Recruiting Sichuan Academy of Medical Sciences · Chengdu, Sichuan · NCT07874594

• Ear-based nerve stimulation to help sleep after a stroke

  A device that delivers vagal nerve stimulation through the ear is tested to see if it helps stroke patients in rehab sleep better.

  Recruiting Casa Colina Hospital and Centers for Healthcare · Pomona, California · NCT07858656

• Theta Burst Stimulation to Help Stroke Recovery (Upper and Lower Limbs)

  This trial tests whether applying theta burst stimulation to the motor cortex, in combination with standard rehabilitation, helps people over 45 who recently had a first ischemic stroke recover arm and leg movement.

  Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle · NCT07834333

• Preventing another ischemic stroke with a smart bracelet and app

  This study tests whether a digital prevention program using a wearable and a mobile app can help people who recently had an ischemic stroke reduce the chance of another stroke and improve risk-factor control.

  Recruiting Affiliated Hospital of Nantong University · Nantong, Jiangsu · NCT07825311

• Photon-counting CT to check intracranial stents

  This study tests whether ultra-high-resolution photon-counting CT can reliably visualize intracranial stents and detect in-stent restenosis during follow-up of patients with prior stents.

  Recruiting Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT07769814

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.