Comparing two pain relief techniques for knee surgery
Analgesic Efficacy of IPACK Versus Selective Tibial Nerve Block in Patients Undergoing Total Knee Arthroplasty Under Spinal Anesthesia With an Adductor Canal Block: a Randomized Controlled Double-blinded Trial
NA · Centre Hospitalier Universitaire Vaudois · NCT06179641
This study is testing which of two pain relief methods works better for people having knee surgery to help them feel less pain after the operation.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire Vaudois (other) |
| Locations | 1 site (Lausanne, Vaud) |
| Trial ID | NCT06179641 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to compare the effectiveness of two regional analgesia techniques, IPACK and selective tibial nerve block, in reducing postoperative pain for patients undergoing total knee arthroplasty. Patients will receive spinal anesthesia along with an adductor canal block, followed by either the IPACK block or the selective tibial nerve block. The study will randomly assign 100 patients into two groups of 50, and postoperative pain scores and morphine consumption will be evaluated to determine which technique provides better pain relief.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older scheduled for total knee arthroplasty under spinal anesthesia.
Not a fit: Patients with known allergies to the anesthetics used or those with significant comorbidities such as renal or hepatic insufficiency may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing knee surgery.
How similar studies have performed: Previous studies have shown varying success with regional analgesia techniques, but this specific comparison is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists classification I-III * 18 yo or older * patients scheduled for total knee arthroplasty under central spinal anesthesia * informed consent signed Exclusion Criteria: * Refusal or inability for informed consent * Known allergies to ropivacaine, acetaminophen, ibuprofen, ketorolac, morphine, ondansetron or dexamethasone * Secondary surgical revision * Opioid treatment such as morphine, hydrocodone, hydromorphone, tramadol, methadone, fentanyl, buprenorphine or codeine * Bleeding diathesis * Neurological deficit * Known renal insufficiency (eGFR \<45 ml/min) * Known hepatic insufficiency (Child score B or C) * Alcohol abuse
Where this trial is running
Lausanne, Vaud
- University Hospital of Lausanne — Lausanne, Vaud, Switzerland (RECRUITING)
Study contacts
- Study coordinator: Marta Szyszko du Bois d'Aische
- Email: marta.szyszko@chuv.ch
- Phone: +41795564002
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Analgesia, Arthropathy of Knee, Postoperative Pain, nerve block, pain management, postoperative pain