Comparing two anesthesia methods for stroke surgery
Target-controlled Total Intravenous Anesthesia With Propofol Versus Sevoflurane Anesthesia for Endovascular Thrombectomy Procedure in Acute Ischemic Stroke Patients: Comparison of the Outcomes
NA · Taipei Veterans General Hospital, Taiwan · NCT05493813
This study is testing which anesthesia method—total intravenous anesthesia or volatile anesthesia—helps people recovering from stroke surgery have better brain function and less confusion afterward.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 298 (estimated) |
| Ages | 20 Years to 90 Years |
| Sex | All |
| Sponsor | Taipei Veterans General Hospital, Taiwan (other gov) |
| Locations | 1 site (Taipei) |
| Trial ID | NCT05493813 on ClinicalTrials.gov |
What this trial studies
This clinical trial compares the effects of total intravenous anesthesia (TIVA) using propofol and volatile anesthesia with sevoflurane on postoperative delirium and cognitive dysfunction in patients undergoing endovascular thrombectomy for acute ischemic stroke. The study aims to regulate sedation depth using processed electroencephalogram monitoring and control peri-procedural blood pressure according to guidelines. By evaluating these two anesthesia modalities, the researchers seek to identify which method may lead to better outcomes in terms of cognitive function and delirium after the procedure.
Who should consider this trial
Good fit: Ideal candidates are adults aged 20 to 90 with a clinical diagnosis of acute ischemic stroke and large vessel occlusion scheduled for endovascular thrombectomy.
Not a fit: Patients with allergies to the anesthetics used in the study or those who refuse to enroll will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help identify a safer anesthesia method that reduces the risk of postoperative delirium and cognitive dysfunction in stroke patients.
How similar studies have performed: Previous studies have indicated that both general anesthesia and sedation are safe for stroke procedures, but this specific comparison of TIVA versus sevoflurane is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of acute ischemic stroke with large vessel occlusion who are scheduled to undergo endovascular thrombectomy procedure, and * Must be age of 20 to 90 * Must fulfill the indications for endovascular thrombectomy in acute ischemic stroke according to the American Heart Association/American Stroke Association 2018 Guidelines for the early management of patients with acute ischemic stroke and 2019 Taiwan stroke society guideline for endovascular thrombectomy in acute ischemic stroke, and * Must agree to enroll into the clinical trial and sign the written informed consent from patients or delegates Exclusion Criteria: * Allergy to allergy to the anesthetics used in this clinical study * Refusal for enrolling in study
Where this trial is running
Taipei
- Taipei Veterans General Hospital — Taipei, Taiwan (RECRUITING)
Study contacts
- Study coordinator: Chun-Sung Sung, MD, PhD
- Email: cssung@vghtpe.gov.tw
- Phone: 886-2-28757549
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Ischemic Stroke, Acute, Thrombectomy, General Anesthesia, Total Intravenous Anesthesia, Postoperative Delirium, Postoperative Cognitive Dysfunction, ischemic stroke, general anesthesia