Comparing Norepinephrine and Phenylephrine for Blood Pressure Control During Cesarean Delivery
Official title: Manually Controlled Continuous Infusion of Norepinephrine vs Phenylephrine During Spinal Anesthesia for Cesarean Section: A Double-blinded Randomized Controlled Study
Run by Hassan II University · NCT06248593 · Data updated 2026-11-12
This study is testing whether using norepinephrine instead of phenylephrine can better control blood pressure during cesarean deliveries with spinal anesthesia.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 140 (estimated) |
| Sponsor | Hassan II University Academic / other |
| Locations | 2 sites (Fes and 1 other locations) |
| Status | Recruiting |
| Started | January 29, 2025 |
| Main results expected | March 15, 2026 |
| Study ends | March 15, 2026 |
| Registry record updated | September 9, 2025 |
| Trial ID | NCT06248593 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include full-term, singleton, non-laboring pregnant women scheduled for elective cesarean delivery under spinal anesthesia with stable baseline blood pressure.
✕Probably not a fit
Patients with known fetal abnormalities, preexisting hypertension, or contraindications to spinal anesthesia may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to compare the effects of continuous infusion of norepinephrine versus phenylephrine on blood pressure maintenance during spinal anesthesia for elective cesarean sections. It is a randomized, double-blind, two-arm, parallel, non-inferiority trial conducted at Hassan II University Hospital in Fes, Morocco. Participants will receive either norepinephrine or phenylephrine, with infusion rates adjusted based on maternal arterial pressure, to assess differences in neonatal outcomes and maternal hemodynamics.
Why it matters
Potential benefit: If successful, this study could improve blood pressure management during cesarean deliveries, leading to better outcomes for both mothers and their newborns.
How similar studies have gone: Previous studies have shown varying results with similar approaches, but this specific comparison of norepinephrine and phenylephrine in this context is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Full-term, singleton, pregnant women, nonlaboring. * Scheduled for elective cesarean delivery under spinal anesthesia, * American Society of Anesthesiologists physical status : 1 or 2 * Baseline systolic BP between 90 and 140 mm Hg. Exclusion Criteria: * Known fetal abnormality. * Preexisting or pregnancy-induced hypertension, cardiovascular, cerebrovascular or kidney disease. * Contraindication to spinal anesthesia. * Peripartum hemorrhage. * Body mass index above 40 kg/m2.
Where it's running
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University hospital Hassan II
Fes, Morocco Recruiting -
University hospital Hassan II
Fes, Morocco Not yet recruiting
Study contacts
- Principal investigator: Mohamed Adnane Berdai, MD-PhD — University hospital Hassan II, Fes, Morocco
- Study coordinator: Mohamed Adnane Berdai, MD-PhD
- Email: adnane.berdai@yahoo.fr
- Phone: +212655260752
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.