Comparing how long local anesthetics last in dermatologic surgery
Official title: Characterizing and Comparing the Duration of Local Anesthetic in Dermatologic Surgery - Fourth Arm
Run by Weill Medical College of Cornell University · NCT06694714 · Data updated 2026-11-12
This study is testing whether using different amounts of a local anesthetic during skin surgery affects how long the numbness lasts, especially in areas with lots of blood vessels.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 35 (estimated) |
| Sponsor | Weill Medical College of Cornell University Academic / other |
| Locations | 1 site (New York, New York) |
| Status | Recruiting |
| Started | January 21, 2025 |
| Main results expected | June 1, 2027 |
| Study ends | June 1, 2027 |
| Registry record updated | January 22, 2026 |
| Trial ID | NCT06694714 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with normal skin sensation at the nasal ala who can provide informed consent.
✕Probably not a fit
Patients with a history of adverse reactions to local anesthetics or those who are pregnant or breastfeeding may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the duration of action of local anesthetics used in dermatologic surgery, specifically focusing on how the volume of anesthetic affects its effectiveness at highly vascular sites. The researchers will compare two different volumes of lidocaine with epinephrine injected at the nasal ala and assess the duration of anesthesia using a non-invasive pinprick testing method. The goal is to determine if varying volumes of the same anesthetic lead to significant differences in duration of action, considering the vascularity of the injection site.
Why it matters
Potential benefit: If successful, this study could optimize the use of local anesthetics, leading to improved pain management during dermatologic procedures.
How similar studies have gone: Previous studies have explored similar methodologies, but this specific investigation into the effects of anesthetic volume at vascular sites is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female ≥ 18 years of age * Normal skin sensation at both nasal ala assessed by pinprick * Ability to provide informed consent Exclusion Criteria: * Previous adverse reaction to local anesthetic or any components of the local anesthetics being evaluated * Pregnant or breastfeeding volunteers (assessed by self-report) * Patients taking monoamineoxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types
Where it's running
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Weill Cornell Medicine
New York, New York, United States Recruiting
Study contacts
- Principal investigator: Kira Minkis, MD, PhD — Weill Medical College of Cornell University
- Study coordinator: Benedict Ho, BA
- Email: beh2024@med.cornell.edu
- Phone: 646-962-6647
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.