Clinical trial Recruiting at 1 site Phase 4 Interventional Ages 18 and up

Comparing how long local anesthetics last in dermatologic surgery

Official title: Characterizing and Comparing the Duration of Local Anesthetic in Dermatologic Surgery - Fourth Arm

Run by Weill Medical College of Cornell University · NCT06694714 · Data updated 2026-11-12

This study is testing whether using different amounts of a local anesthetic during skin surgery affects how long the numbness lasts, especially in areas with lots of blood vessels.

Quick facts

PhasePhase 4
Study typeInterventional
Ages18 Years and up
SexAll
Enrollment35 (estimated)
SponsorWeill Medical College of Cornell University
Academic / other
Locations1 site (New York, New York)
StatusRecruiting
StartedJanuary 21, 2025
Main results expectedJune 1, 2027
Study endsJune 1, 2027
Registry record updatedJanuary 22, 2026
Trial IDNCT06694714 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older with normal skin sensation at the nasal ala who can provide informed consent.

Probably not a fit

Patients with a history of adverse reactions to local anesthetics or those who are pregnant or breastfeeding may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the duration of action of local anesthetics used in dermatologic surgery, specifically focusing on how the volume of anesthetic affects its effectiveness at highly vascular sites. The researchers will compare two different volumes of lidocaine with epinephrine injected at the nasal ala and assess the duration of anesthesia using a non-invasive pinprick testing method. The goal is to determine if varying volumes of the same anesthetic lead to significant differences in duration of action, considering the vascularity of the injection site.

Why it matters

Potential benefit: If successful, this study could optimize the use of local anesthetics, leading to improved pain management during dermatologic procedures.

How similar studies have gone: Previous studies have explored similar methodologies, but this specific investigation into the effects of anesthetic volume at vascular sites is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Male or female ≥ 18 years of age
* Normal skin sensation at both nasal ala assessed by pinprick
* Ability to provide informed consent

Exclusion Criteria:

* Previous adverse reaction to local anesthetic or any components of the local anesthetics being evaluated
* Pregnant or breastfeeding volunteers (assessed by self-report)
* Patients taking monoamineoxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types

Where it's running

  • Weill Cornell Medicine
    New York, New York, United States
    Recruiting

Study contacts

  • Principal investigator: Kira Minkis, MD, PhD — Weill Medical College of Cornell University
  • Study coordinator: Benedict Ho, BA
  • Email: beh2024@med.cornell.edu
  • Phone: 646-962-6647

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.