Comparing how long local anesthetics last in dermatologic surgery
Characterizing and Comparing the Duration of Local Anesthetic in Dermatologic Surgery - Fourth Arm
This study is testing whether using different amounts of a local anesthetic during skin surgery affects how long the numbness lasts, especially in areas with lots of blood vessels.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 35 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Weill Medical College of Cornell University Academic / other |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT06694714 on ClinicalTrials.gov |
What this trial studies
This study investigates the duration of action of local anesthetics used in dermatologic surgery, specifically focusing on how the volume of anesthetic affects its effectiveness at highly vascular sites. The researchers will compare two different volumes of lidocaine with epinephrine injected at the nasal ala and assess the duration of anesthesia using a non-invasive pinprick testing method. The goal is to determine if varying volumes of the same anesthetic lead to significant differences in duration of action, considering the vascularity of the injection site.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with normal skin sensation at the nasal ala who can provide informed consent.
Not a fit: Patients with a history of adverse reactions to local anesthetics or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could optimize the use of local anesthetics, leading to improved pain management during dermatologic procedures.
How similar studies have performed: Previous studies have explored similar methodologies, but this specific investigation into the effects of anesthetic volume at vascular sites is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female ≥ 18 years of age * Normal skin sensation at both nasal ala assessed by pinprick * Ability to provide informed consent Exclusion Criteria: * Previous adverse reaction to local anesthetic or any components of the local anesthetics being evaluated * Pregnant or breastfeeding volunteers (assessed by self-report) * Patients taking monoamineoxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types
Where this trial is running
New York, New York
- Weill Cornell Medicine — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Kira Minkis, MD, PhD — Weill Medical College of Cornell University
- Study coordinator: Benedict Ho, BA
- Email: beh2024@med.cornell.edu
- Phone: 646-962-6647
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.