Identifying risks for cardiovascular and neurocognitive diseases using biomarkers
Screening for Biomarkers of Cardiovascular and/or Neurological Fragility: A Longitudinal Prospective Cohort Study Based on the Population Under General Anesthesia
Assistance Publique - Hôpitaux de Paris · NCT05951764
This study is trying to see if measuring certain markers in the blood can help identify people over 45 who are at risk for heart and brain diseases before they have surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 396 (estimated) |
| Ages | 45 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris (other) |
| Locations | 1 site (Paris) |
| Trial ID | NCT05951764 on ClinicalTrials.gov |
What this trial studies
This observational study aims to improve the early identification of individuals at risk for cardiovascular disease and neurodegenerative conditions by utilizing biomarkers. It focuses on patients over 45 years old who are scheduled for outpatient or interventional procedures requiring anesthesia. By measuring arterial stiffness through non-invasive techniques, the study seeks to validate predictive models that can lead to timely preventive therapies. The perioperative period is leveraged as an optimal time for screening due to the direct benefits patients receive from anesthesia consultations.
Who should consider this trial
Good fit: Ideal candidates are patients over 45 years old undergoing outpatient or scheduled surgeries requiring anesthesia.
Not a fit: Patients under 45 years of age or those opposed to participation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enable earlier interventions that prevent serious cardiovascular and neurocognitive complications.
How similar studies have performed: While there are numerous predictive models for these conditions, few have been validated in similar settings, making this approach relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients \> 45 years old * Eligible for outpatient or scheduled surgery or interventional procedures under general anesthesia or locoregional anesthesia with sedation. * Patient having expressed no objection to participation in this research. * Patient who is not subject to a legal protection measure Exclusion Criteria: * Patients under 45 years of age. * Patient opposed to participation in the protocol * Pregnant woman * Patient under judicial protection * Patient not affiliated to a social health system
Where this trial is running
Paris
- AP-HP, Lariboisière Hospital, Department of Anesthesiology and Intensive Care — Paris, France (RECRUITING)
Study contacts
- Study coordinator: Joaquim MATEO, MD
- Email: joaquim.mateo@aphp.fr
- Phone: 149958374
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Anesthesia, Local, Anesthesia, Predictive medicine, Cardiovascular biomarkers, Neurocognitive Biomarkers