Clinical trial Recruiting at 1 site Observational Ages 45 and up

Identifying risks for cardiovascular and neurocognitive diseases using biomarkers

Official title: Screening for Biomarkers of Cardiovascular and/or Neurological Fragility: A Longitudinal Prospective Cohort Study Based on the Population Under General Anesthesia

Run by Assistance Publique - Hôpitaux de Paris · NCT05951764 · Data updated 2026-11-12

This study is trying to see if measuring certain markers in the blood can help identify people over 45 who are at risk for heart and brain diseases before they have surgery.

Quick facts

Study typeObservational
Ages45 Years and up
SexAll
Enrollment396 (estimated)
SponsorAssistance Publique - Hôpitaux de Paris
Academic / other
Locations1 site (Paris)
StatusRecruiting
StartedMay 2024
Main results expectedMay 2029
Study endsMay 2032
Registry record updatedApril 30, 2024
Trial IDNCT05951764 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients over 45 years old undergoing outpatient or scheduled surgeries requiring anesthesia.

Probably not a fit

Patients under 45 years of age or those opposed to participation will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to improve the early identification of individuals at risk for cardiovascular disease and neurodegenerative conditions by utilizing biomarkers. It focuses on patients over 45 years old who are scheduled for outpatient or interventional procedures requiring anesthesia. By measuring arterial stiffness through non-invasive techniques, the study seeks to validate predictive models that can lead to timely preventive therapies. The perioperative period is leveraged as an optimal time for screening due to the direct benefits patients receive from anesthesia consultations.

Why it matters

Potential benefit: If successful, this study could enable earlier interventions that prevent serious cardiovascular and neurocognitive complications.

How similar studies have gone: While there are numerous predictive models for these conditions, few have been validated in similar settings, making this approach relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients \> 45 years old
* Eligible for outpatient or scheduled surgery or interventional procedures under general anesthesia or locoregional anesthesia with sedation.
* Patient having expressed no objection to participation in this research.
* Patient who is not subject to a legal protection measure

Exclusion Criteria:

* Patients under 45 years of age.
* Patient opposed to participation in the protocol
* Pregnant woman
* Patient under judicial protection
* Patient not affiliated to a social health system

Where it's running

  • AP-HP, Lariboisière Hospital, Department of Anesthesiology and Intensive Care
    Paris, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.