Identifying risks for cardiovascular and neurocognitive diseases using biomarkers
Official title: Screening for Biomarkers of Cardiovascular and/or Neurological Fragility: A Longitudinal Prospective Cohort Study Based on the Population Under General Anesthesia
Run by Assistance Publique - Hôpitaux de Paris · NCT05951764 · Data updated 2026-11-12
This study is trying to see if measuring certain markers in the blood can help identify people over 45 who are at risk for heart and brain diseases before they have surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 45 Years and up |
| Sex | All |
| Enrollment | 396 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | May 2024 |
| Main results expected | May 2029 |
| Study ends | May 2032 |
| Registry record updated | April 30, 2024 |
| Trial ID | NCT05951764 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients over 45 years old undergoing outpatient or scheduled surgeries requiring anesthesia.
✕Probably not a fit
Patients under 45 years of age or those opposed to participation will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to improve the early identification of individuals at risk for cardiovascular disease and neurodegenerative conditions by utilizing biomarkers. It focuses on patients over 45 years old who are scheduled for outpatient or interventional procedures requiring anesthesia. By measuring arterial stiffness through non-invasive techniques, the study seeks to validate predictive models that can lead to timely preventive therapies. The perioperative period is leveraged as an optimal time for screening due to the direct benefits patients receive from anesthesia consultations.
Why it matters
Potential benefit: If successful, this study could enable earlier interventions that prevent serious cardiovascular and neurocognitive complications.
How similar studies have gone: While there are numerous predictive models for these conditions, few have been validated in similar settings, making this approach relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients \> 45 years old * Eligible for outpatient or scheduled surgery or interventional procedures under general anesthesia or locoregional anesthesia with sedation. * Patient having expressed no objection to participation in this research. * Patient who is not subject to a legal protection measure Exclusion Criteria: * Patients under 45 years of age. * Patient opposed to participation in the protocol * Pregnant woman * Patient under judicial protection * Patient not affiliated to a social health system
Where it's running
-
AP-HP, Lariboisière Hospital, Department of Anesthesiology and Intensive Care
Paris, France Recruiting
Study contacts
- Study coordinator: Joaquim MATEO, MD
- Email: joaquim.mateo@aphp.fr
- Phone: 149958374
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.