Clips to prevent bleeding after colon polyp removal in people restarting blood thinners
Official title: Prevention of Post-Polypectomy Colorectal Bleeding by Clips in Patients on Anticoagulants: a Retrospective Single Center Propensity Score Analysis
Run by Helios Kliniken Schwerin · NCT07007598 · Data updated 2026-11-12
This work will test whether placing clips on the polyp removal site prevents bleeding in adults who restart anticoagulant medications (excluding aspirin) after colon polyp removal.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 10000 (estimated) |
| Sponsor | Helios Kliniken Schwerin Academic / other |
| Locations | 1 site (Schwerin, Mecklenburg-Vorpommern) |
| Status | Recruiting |
| Started | May 1, 2025 |
| Main results expected | May 1, 2026 |
| Study ends | November 1, 2026 |
| Registry record updated | June 18, 2025 |
| Trial ID | NCT07007598 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults who underwent colorectal polypectomy and subsequently restarted systemic anticoagulant therapy (other than aspirin) are the intended population for this analysis.
✕Probably not a fit
Patients whose mucosal defects were closed with a suturing device or full-thickness resection device, patients who never restarted anticoagulants, or those only on aspirin would not be expected to benefit from the conclusions of this analysis.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a retrospective, observational analysis using a large single-center registry of more than 10,000 colonoscopies to compare adults who received preventive hemostatic clips after polypectomy with those who did not. The population of interest is patients who restarted anticoagulant therapy after the procedure (acetylsalicylic acid excluded). Researchers will compare rates of post-polypectomy colorectal bleeding after anticoagulant restart and exclude cases where closure was performed with a suturing device or full-thickness resection device. The goal is to determine whether routine preventive clipping is associated with lower delayed bleeding in this anticoagulated population.
Why it matters
Potential benefit: If effective, prophylactic clipping could lower delayed bleeding rates after polypectomy in patients who resume anticoagulants, reducing complications and need for additional interventions.
How similar studies have gone: Prior studies and guidelines report mixed results—selective clipping and clipping large right-sided EMR defects can reduce bleeding, but evidence is inconsistent and there is no clear recommendation specific to patients on anticoagulants.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult who has received a colonoscopy with endoscopic colorectal polypectomy * patient who has received at least one anticoagulant after polypectomy Exclusion Criteria: * Endoscopic polypectomy was combined with closure of the mucosal defect by a suturing device or full thickness resection device
Where it's running
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Helios Kliniken Schwerin
Schwerin, Mecklenburg-Vorpommern, Germany Recruiting
Study contacts
- Principal investigator: Daniel Schmitz, Dr.med. — Helios Kliniken Schwerin
- Study coordinator: Daniel Schmitz, Dr. med.
- Email: Daniel.Schmitz@helios-gesundheit.de
- Phone: +493855202601
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.