Comparing closure techniques after removing large colorectal polyps

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the rates of adverse events and lesion recurrence following endoscopic mucosal resection (EMR) of large flat colorectal polyps, specifically laterally spreading lesions. Participants will be randomly assigned to either a control group, where no defect closure is performed, or an experimental group, where complete defect closure is applied after EMR. The study will monitor patients for adverse events and recurrence through follow-up assessments at 6 and 18 months post-procedure. The trial is designed to determine if defect closure can reduce complications associated with EMR.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* adult ≥18 years old
* patients undergoing EMR for a large (≥20mm) colorectal LSL
* patients providing written and informed consent for study participation.

Exclusion Criteria:

* inflammatory bowel disease;
* non-elective colonoscopy;
* poor general health (American Society of Anesthesiologists classification \>III);
* coagulopathy or thrombocytopenia (international normalized ratio ≥1.5 or platelets \<50 x 109/L);
* pedunculated polyps (Paris class Ip, Isp);
* overt signs of deep submucosal invasive cancer (JNET 3);
* appendiceal orifice or terminal ileum invasion;
* pregnancy.

Where it's running

• Centre Hospitalier de l'Université de Montréal
  Montreal, Quebec, Canada Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.