Reducing recurrence of large colorectal polyps after removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of hybrid argon plasma coagulation (h-APC) in reducing the recurrence of large colorectal polyps after endoscopic mucosal resection (EMR). Patients with large laterally spreading lesions (≥20mm) will be randomly assigned to receive either h-APC ablation or the standard snare tip soft coagulation (STSC) margin ablation. The trial aims to determine if the h-APC technique leads to lower rates of lesion recurrence compared to the current standard of care. Participants will undergo a standard colonoscopy preparation before the procedure, and the trial will be conducted at a single center in Montreal.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* adult ≥18 years old
* patients undergoing EMR for a large (≥20mm) colorectal LSL
* patients providing written and informed consent for study participation.

Exclusion Criteria:

* inflammatory bowel disease;
* non-elective colonoscopy;
* poor general health (American Society of Anesthesiologists classification \>III);
* coagulopathy or thrombocytopenia (international normalized ratio ≥1.5 or platelets \<50 x 109/L);
* pedunculated polyps (Paris class Ip, Isp);
* overt signs of deep submucosal invasive cancer (JNET 3);
* biopsy proven invasive carcinoma in a potential study polyp.
* Pregnant women

Where it's running

• Centre Hospitalier de l'Université de Montréal
  Montreal, Quebec, Canada Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.