Comparing adipokine levels in women with and without PCOS
Assessment of Adipokine Concentrations and Their Association With the Metabolic Profile of Women With PCOS
This study is trying to see how levels of certain fat-related proteins differ in women with polycystic ovary syndrome (PCOS), both with and without insulin resistance, compared to women without PCOS.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | Jagiellonian University Academic / other |
| Locations | 1 site (Krakow) |
| Trial ID | NCT06793072 on ClinicalTrials.gov |
What this trial studies
This observational study aims to measure and compare the concentrations of adipokines, specifically leptin, resistin, and omentin-1, in three groups of women: those with polycystic ovary syndrome (PCOS) without insulin resistance, those with PCOS with insulin resistance, and women without PCOS. The study seeks to elucidate the role of these adipokines in the etiology of PCOS and their association with insulin resistance, which is linked to various health complications. Blood samples will be analyzed using immunoenzymatic methods (ELISA) and a biochemical analyzer to determine the concentrations of the selected adipokines.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 18-45 who have been diagnosed with polycystic ovary syndrome or are healthy controls without PCOS.
Not a fit: Patients who have had at least one ovary removed, or those with treated diabetes, metabolic diseases, autoimmune diseases, or autoinflammatory diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and identification of biomarkers for insulin resistance in women with PCOS, potentially improving management and treatment strategies.
How similar studies have performed: While the role of adipokines in PCOS has been explored, this study's specific focus on comparing these markers across different PCOS phenotypes is a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-45 Exclusion Criteria: * previous removal of at least one ovary * treated diabetes of any type * diagnosed and treated metabolic diseases * diagnosed and treated autoimmune diseases * diagnosed and treated autoinflammatory diseases(Edited)Restore original
Where this trial is running
Krakow
- Jagiellonian Univeristy — Krakow, Poland (Recruiting)
Study contacts
- Study coordinator: Iwona Gawron, Ph.D., M.D.
- Email: iwona.gawron@uj.edu.pl
- Phone: +48 124248570
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.