Collecting tissue samples to study central nervous system tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to enhance understanding of central nervous system (CNS) tumors by collecting tissue samples during surgeries and post-autopsy. The collected samples will undergo various analyses, including DNA and RNA extraction, sequencing, and drug screening to develop new treatment options. The research will also involve creating tumor cell lines and patient-derived xenografts to test responses to different drugs. Additionally, biological samples from pediatric patients without CNS tumors will be collected for comparative analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria for Tumor patients undergoing neurosurgery (cohort 1)

1. Subject has presented with a suspected/confirmed neoplastic CNS lesion and is undergoing a neurosurgical procedure in which CNS tissue and/or tumors associated with this tissue will be removed.
2. There must be tissue available in excess of that required by neuropathology for diagnostic purposes.
3. Subject of all ages included.
4. Subjects who are pregnant can be included.
5. Subjects who are neonates (0-4 weeks) can be included.

Inclusion Criteria for Non-tumor patients undergoing neurosurgery (cohort 2)

1. Subject is between 4 weeks and 21 years of age and is undergoing a neurosurgical procedure at WCMC.
2. Subject does not have a CNS tumor diagnosis.
3. Subject should not be pregnant at the time of enrollment.

Inclusion Criteria for Autopsy tumor tissue donation (cohort 3)

1. Subject of all ages included
2. Subject has been diagnosed with a neoplastic CNS lesion at the time of passing.
3. Subjects who are pregnant can be included.
4. Subjects who are neonates (0-4 weeks) can be included.

Inclusion Criteria for parent of tumor patients

1. Subject is the biological parent of a patient undergoing/ who underwent a neurosurgical procedure in which CNS tissue and/or tumors associated with this tissue will be/ was removed.
2. Subject is the biological parent of patient enrolled in cohort 1.
3. Subject is not pregnant at the time of enrollment.

Where it's running

• Weill Cornell Medicine
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Jeffrey Greenfield, M.D. — Weill Medical College of Cornell University
• Study coordinator: Jeffrey Greenfield, M.D.
• Email: jpgreenf@med.cornell.edu
• Phone: 212-746-2363

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.