Collecting tissue samples to study central nervous system tumors
Tissue Collection for Drug Screening and Bioanalysis
This study is collecting tissue samples from surgeries and autopsies to learn more about central nervous system tumors and find new treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Sex | All |
| Sponsor | Weill Medical College of Cornell University Academic / other |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT04852354 on ClinicalTrials.gov |
What this trial studies
This study aims to enhance understanding of central nervous system (CNS) tumors by collecting tissue samples during surgeries and post-autopsy. The collected samples will undergo various analyses, including DNA and RNA extraction, sequencing, and drug screening to develop new treatment options. The research will also involve creating tumor cell lines and patient-derived xenografts to test responses to different drugs. Additionally, biological samples from pediatric patients without CNS tumors will be collected for comparative analysis.
Who should consider this trial
Good fit: Ideal candidates include patients of all ages undergoing neurosurgery for suspected or confirmed CNS tumors, as well as pediatric patients without CNS tumors undergoing neurological procedures.
Not a fit: Patients who are not undergoing neurosurgery or do not have a CNS tumor diagnosis may not receive any benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and new therapeutic targets for patients with CNS tumors.
How similar studies have performed: Other studies have shown promise in using tissue samples for drug screening and analysis in cancer research, indicating that this approach has potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria for Tumor patients undergoing neurosurgery (cohort 1) 1. Subject has presented with a suspected/confirmed neoplastic CNS lesion and is undergoing a neurosurgical procedure in which CNS tissue and/or tumors associated with this tissue will be removed. 2. There must be tissue available in excess of that required by neuropathology for diagnostic purposes. 3. Subject of all ages included. 4. Subjects who are pregnant can be included. 5. Subjects who are neonates (0-4 weeks) can be included. Inclusion Criteria for Non-tumor patients undergoing neurosurgery (cohort 2) 1. Subject is between 4 weeks and 21 years of age and is undergoing a neurosurgical procedure at WCMC. 2. Subject does not have a CNS tumor diagnosis. 3. Subject should not be pregnant at the time of enrollment. Inclusion Criteria for Autopsy tumor tissue donation (cohort 3) 1. Subject of all ages included 2. Subject has been diagnosed with a neoplastic CNS lesion at the time of passing. 3. Subjects who are pregnant can be included. 4. Subjects who are neonates (0-4 weeks) can be included. Inclusion Criteria for parent of tumor patients 1. Subject is the biological parent of a patient undergoing/ who underwent a neurosurgical procedure in which CNS tissue and/or tumors associated with this tissue will be/ was removed. 2. Subject is the biological parent of patient enrolled in cohort 1. 3. Subject is not pregnant at the time of enrollment.
Where this trial is running
New York, New York
- Weill Cornell Medicine — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Jeffrey Greenfield, M.D. — Weill Medical College of Cornell University
- Study coordinator: Jeffrey Greenfield, M.D.
- Email: jpgreenf@med.cornell.edu
- Phone: 212-746-2363
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.