Predicting and preventing surgical wound infections after brain or spinal tumor surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study uses an intelligent prediction model to generate individualized risk scores for patients undergoing elective craniotomy or spinal tumor resection and applies an enhanced bundle of preventive measures for those identified as high risk while others receive standard postoperative care. The model is built with machine learning and explainable AI methods (including SHAP) to make risk drivers transparent to clinicians. Eligible adults with pathologically confirmed primary or metastatic CNS tumors will be enrolled at a single center and followed for postoperative surgical site infections. The primary goal is to compare infection rates between model-guided enhanced prevention and standard care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients with a pathologically confirmed primary or metastatic central nervous system (brain or spinal) tumor.
2. Scheduled for elective craniotomy or spinal tumor resection surgery.
3. Age ≥ 18 years.
4. Expected survival \> 3 months, and able/willing to comply with postoperative follow-up.
5. Voluntary participation and provision of written informed consent.

Exclusion Criteria:

1. Presence of active systemic or local surgical site infection before surgery.
2. Use of therapeutic antibiotics for any reason within 72 hours prior to surgery.
3. Concurrent severe immunosuppressive conditions, or chronic use of high-dose immunosuppressants.
4. Pregnancy or lactation.
5. Known contraindications or severe allergy to the antibiotics planned for use in the study.
6. Any other condition that, in the investigator's judgment, may affect study participation or outcome assessment.

Where it's running

• National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
  Beijing, Pumc, China Recruiting

Study contacts

• Study coordinator: Ming Yang, MD
• Email: yangming@cicams.ac.cn
• Phone: +8613810655237

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.