Using ozonized olive oil to treat periodontal pockets
Clinical and Microbiological Study on Local Application of an Ozonated Olive Oil Gel in the Periodontal Pockets: a Randomized Double-blind Trial.
This study tests whether ozonized olive oil gel can help people with chronic periodontitis reduce their periodontal pockets better than a placebo gel.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Bari Academic / other |
| Locations | 1 site (Bari, BA) |
| Trial ID | NCT06980675 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of ozonized olive oil gel in treating periodontal pockets in patients diagnosed with chronic periodontitis. Sixteen participants were randomly assigned to either an experimental group receiving the ozonized olive oil gel or a control group receiving a placebo gel. After an initial hygiene treatment to remove tartar, the participants underwent a series of evaluations and gel administrations over a three-week period, including periodontal probing and microbiological sampling to assess treatment outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 with stage II, III, or IV periodontitis and probing pocket depth of 4 mm or more.
Not a fit: Patients with conditions such as diabetes, severe smoking habits, or those undergoing immunosuppressive therapies may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could offer a novel and effective option for managing periodontal disease.
How similar studies have performed: While there is limited data on the use of ozonized olive oil specifically, similar studies on ozonated therapies have shown promising results in periodontal treatment.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with stage II, III, or IV periodontitis according to the new 2017 World Workshop periodontal classification * Patients of either sex and older than 18 years of age * Probing Pocket Depth (PPD) greater than or equal to 4 mm at 3 sites * Patients who have signed consent to the study * Collaborating patients Exclusion Criteria: * age \< 18 years and/or inability to provide written informed consent; * absence of family or social welfare support; * non-drug-induced gingival hypertrophy, * severe smokers (more than 20 cigarettes per day), * consumers of high levels of alcohol, * patients on corticosteroid treatment, * diabetic patient, * immunodepressive therapies, * chemotherapies, * radiotherapies, * pregnancy states; * lack of collaboration for ongoing postoperative reevaluations.
Where this trial is running
Bari, BA
- Odontostomatologic Departement of Policlinic of Bari — Bari, Ba, Italy (Recruiting)
Study contacts
- Principal investigator: Massimo Petruzzi, PhD, MD — University of Bari
- Study coordinator: Fabio Vittorio Ciccone, MD
- Email: fabio.ciccone5@gmail.com
- Phone: 3887589165
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.