MIST with PRF versus GBT (with or without PRF) for treating a single deep intrabony periodontal defect

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, randomized controlled trial that enrolls adults with a solitary intrabony defect ≥4 mm and randomizes them to three arms: GBT alone (control), non-surgical GBT with PRF placed into the cleaned defect, or MIST with PRF placed after flap access. Clinical periodontal parameters are recorded at baseline and at six months and standardized radiographs are taken at six months to measure bone changes. The primary outcome is the change in clinical attachment level (delta CAL) at six months, with radiographic bone fill and standard clinical measures as secondary outcomes. Key eligibility includes good oral hygiene, low plaque and bleeding scores, minimal smoking, and no furcation involvement.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* solitaire intrabony periodontal defect at least 4 mm

Exclusion Criteria:

* Periodontitis with intrabony defect (Intrabony component ≥ 4mm, defect radiological angulation \> 25°,
* The patient is able to comply with the study -related procedures (i.e. good level of oral hygiene, follow-up procedures).
* Patients must not be heavy smokers (\<5 cigarettes/day).
* furcation involvement
* Full mouth plaque and bleeding scores (FMPS and FMBS) of \<15% (O'Leary et al. 1972).
* The patient is able to fully understand the nature of the study, signed informed consent.

Where it's running

• Semmelweis University Department of Periodontology
  Budapest, Budapest, Hungary Recruiting

Study contacts

• Study coordinator: Pál Nagy, DMD
• Email: kardpali@gmail.com
• Phone: +3613185222

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.