Choroidal venous flow changes after scleral buckle for retinal detachment
Choroidal Venous Congestion Following Scleral Buckling - An Imaging Study
This project will use serial eye imaging to see if scleral buckle surgery changes choroidal blood flow and vessel structure in adults having their first retinal detachment repair.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 21 Years and up |
| Sex | All |
| Sponsor | Singapore National Eye Centre Government |
| Locations | 1 site (Singapore) |
| Trial ID | NCT07260097 on ClinicalTrials.gov |
What this trial studies
Scleral buckle surgery places an external silicone band around the eye to support retinal breaks, and investigators hypothesize this may increase resistance in choroidal venous outflow. The study will follow patients who undergo scleral buckle (with or without vitrectomy or cataract surgery) using repeated imaging of the back of the eye to document quantitative and qualitative changes in choroidal vessels over time. Investigators expect initial alterations in vessel structure that progressively stabilize and may revert toward baseline with long-term remodeling. Findings will be compared opportunistically with the clinically normal fellow eye to characterize the pattern and time course of any venous congestion.
Who should consider this trial
Good fit: Adults aged 21 or older with a first retinal detachment in one eye planned for scleral buckle surgery (with or without vitrectomy or cataract surgery) and a clinically normal fellow eye who can give informed consent are ideal candidates.
Not a fit: Patients who have had prior intraocular surgery (other than cataract extraction with lens implant), who require other vitreoretinal procedures, who are pregnant or nursing, or who cannot give informed consent are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the findings could improve understanding of how scleral buckle surgery affects choroidal blood flow and help inform better management of related retinal diseases such as AMD and PCV.
How similar studies have performed: While choroidal imaging has been applied in other retinal conditions, using serial imaging specifically to document venous congestion after scleral buckle is relatively novel and not yet widely validated.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 21 years and above * Ability to provide informed consent * First occurrence of a retinal detachment in one eye, deemed to require SB surgery with or without vitrectomy and/or cataract surgery. * Clinically normal fellow eye (no previous intraocular surgery except for cataract extraction with lens implant, intraocular laser or injection procedures). Exclusion Criteria: * Affected eye undergoing vitreoretinal procedure other than an SB surgery with or without vitrectomy and/or cataract surgery. * Pregnant or nursing women * Persons who are unable to give informed consent
Where this trial is running
Singapore
- Singapore Eye Research Institute — Singapore, Singapore (Recruiting)
Study contacts
- Study coordinator: Gemmy Cheung
- Email: gemmy.cheung.c.m@singhealth.com.sg
- Phone: +6563227460
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.