Progression of choroidal venous changes in pachychoroid
Official title: International Multi-centre, Prospective, Longitudinal Cohort to Evaluate the Progression Pattern of Choroidal Venous Alterations
Run by Singapore National Eye Centre · NCT07236671 · Data updated 2026-11-12
The study will follow adults with pachychoroid to see how their choroidal veins and pachyvessels change over three years.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 45 Years and up |
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | Singapore National Eye Centre Government |
| Locations | 4 sites (Hong Kong and 3 other locations) |
| Status | Recruiting |
| Started | March 4, 2025 |
| Main results expected | June 2029 |
| Study ends | August 2029 |
| Registry record updated | June 12, 2026 |
| Trial ID | NCT07236671 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 45 or older who have pachyvessels visible in at least one quadrant on ultra-widefield imaging and who can undergo pupil dilation and provide informed consent.
✕Probably not a fit
People without pachyvessels, those with other ocular pathologies or uncontrolled systemic diseases that affect ocular blood flow, pregnant or nursing women, and those unable to consent are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will enroll adults with pachyvessels and perform serial ultra-widefield imaging and other protocol assessments over a three-year period. Progression is defined as an increase in the number of quadrants with pachyvessels or formation of new venous anastomoses that cross physiological watershed zones. The study will document incidence rates and detailed longitudinal patterns of choroidal venous alteration. Collected natural-history data will be used to test the proposed multi-hit theory of pachychoroid evolution.
Why it matters
Potential benefit: If successful, the findings could help doctors predict which patients are at higher risk of vision-threatening progression and tailor monitoring and early interventions.
How similar studies have gone: Previous work has described pachyvessels and pachychoroid phenotypes, but longitudinal tracking of choroidal venous anastomoses and formal validation of the multi-hit theory over three years is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adults aged 45 years or older. 2. Presence of pachyvessels on ultra-widefield (UWF) imaging in at least one quadrant. 3. Willing to undergo pupil dilation, and protocol-required procedures for both eyes 4. Willing to provide written informed consent Exclusion Criteria: 1. Presence of disorders of the ocular media which interfere with visual acuity and other ocular assessments during the study period 2. Eyes with other ocular pathology such as trauma, inflammation, previous intraocular surgery (except for cataract surgery) 3. Systemic diseases that might affect ocular blood flow such as uncontrolled hypertension, autoimmune disease, and haematological disorders 4. Pregnant or nursing women 5. Persons who are unable to give informed consent
Where it's running
-
Hong Kong University
Hong Kong, Hong Kong Recruiting -
University of Malaya Medical Centre
Kuala Lumpur, Malaysia Recruiting -
National University Hospital, Singapore
Singapore, Singapore Recruiting -
Singapore National Eye Centre/ Singapore Eye Research Institute
Singapore, Singapore Recruiting
Study contacts
- Study coordinator: Gemmy Cheung
- Email: gemmy.cheung.c.m@singhealth.com.sg
- Phone: +65 63227460
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.