Progression of choroidal venous changes in pachychoroid
International Multi-centre, Prospective, Longitudinal Cohort to Evaluate the Progression Pattern of Choroidal Venous Alterations
Singapore National Eye Centre · NCT07236671
The study will follow adults with pachychoroid to see how their choroidal veins and pachyvessels change over three years.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 250 (estimated) |
| Ages | 45 Years and up |
| Sex | All |
| Sponsor | Singapore National Eye Centre (other gov) |
| Locations | 4 sites (Hong Kong and 3 other locations) |
| Trial ID | NCT07236671 on ClinicalTrials.gov |
What this trial studies
This observational study will enroll adults with pachyvessels and perform serial ultra-widefield imaging and other protocol assessments over a three-year period. Progression is defined as an increase in the number of quadrants with pachyvessels or formation of new venous anastomoses that cross physiological watershed zones. The study will document incidence rates and detailed longitudinal patterns of choroidal venous alteration. Collected natural-history data will be used to test the proposed multi-hit theory of pachychoroid evolution.
Who should consider this trial
Good fit: Adults aged 45 or older who have pachyvessels visible in at least one quadrant on ultra-widefield imaging and who can undergo pupil dilation and provide informed consent.
Not a fit: People without pachyvessels, those with other ocular pathologies or uncontrolled systemic diseases that affect ocular blood flow, pregnant or nursing women, and those unable to consent are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the findings could help doctors predict which patients are at higher risk of vision-threatening progression and tailor monitoring and early interventions.
How similar studies have performed: Previous work has described pachyvessels and pachychoroid phenotypes, but longitudinal tracking of choroidal venous anastomoses and formal validation of the multi-hit theory over three years is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adults aged 45 years or older. 2. Presence of pachyvessels on ultra-widefield (UWF) imaging in at least one quadrant. 3. Willing to undergo pupil dilation, and protocol-required procedures for both eyes 4. Willing to provide written informed consent Exclusion Criteria: 1. Presence of disorders of the ocular media which interfere with visual acuity and other ocular assessments during the study period 2. Eyes with other ocular pathology such as trauma, inflammation, previous intraocular surgery (except for cataract surgery) 3. Systemic diseases that might affect ocular blood flow such as uncontrolled hypertension, autoimmune disease, and haematological disorders 4. Pregnant or nursing women 5. Persons who are unable to give informed consent
Where this trial is running
Hong Kong and 3 other locations
- Hong Kong University — Hong Kong, Hong Kong (NOT_YET_RECRUITING)
- University of Malaya Medical Centre — Kuala Lumpur, Malaysia (RECRUITING)
- National University Hospital, Singapore — Singapore, Singapore (NOT_YET_RECRUITING)
- Singapore National Eye Centre/ Singapore Eye Research Institute — Singapore, Singapore (RECRUITING)
Study contacts
- Study coordinator: Gemmy Cheung
- Email: gemmy.cheung.c.m@singhealth.com.sg
- Phone: +65 63227460
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Pachychoroid Disease