Predictors of outcomes after vitrectomy for myopic foveoschisis
Official title: Structural and Functional Determinants of Surgical Outcomes in Vitrectomy for Myopic Foveoschisis
Run by Singapore National Eye Centre · NCT07774637 · Data updated 2026-11-12
This study tests what factors predict how well vitrectomy helps eyes with myopic foveoschisis in adults with high myopia.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years to 90 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Singapore National Eye Centre Government |
| Locations | 1 site (Singapore, Singapore) |
| Status | Recruiting |
| Started | June 10, 2024 |
| Main results expected | June 10, 2028 |
| Study ends | June 10, 2029 |
| Registry record updated | August 19, 2026 |
| Trial ID | NCT07774637 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 40–90 with high myopia (>-6 D or axial length >26 mm) and myopic foveoschisis requiring surgery due to progressive vision loss.
✕Probably not a fit
Patients with non-surgical ocular conditions or ungradable imaging, or those not meeting surgical criteria, may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective pilot study enrolls 30 adults with high myopia and myopic foveoschisis requiring surgery at the Singapore National Eye Centre. It aims to identify structural and functional determinants of surgical outcomes after pars plana vitrectomy, including ILM peeling approaches, to see which preoperative factors correlate with visual and anatomical recovery. Participants will undergo standard vitrectomy procedures with documented imaging and follow-up to assess outcomes over time. The study provides context for timing and patient selection in a condition where optimal surgical timing is not well defined. Results could help tailor surgical decisions to individual patients.”,
Why it matters
Potential benefit: If successful, the study could help clinicians predict which patients are most likely to benefit from vitrectomy.
How similar studies have gone: Prior research supports vitrectomy for relieving traction in MFS, but predictors of visual recovery are still being explored.
Who can join: the full rules
Show full inclusion / exclusion criteria
The target population is 30 adults with high myopia and MFS requiring vitrectomy. inclusion critieria * Be 40-90 years old. * Have high myopia, defined as refractive error worse than -6 dioptres and axial length longer than 26 mm. * Be mentally competent to provide informed consent. * Have MFS that meets clinical criteria for surgical intervention, specifically:progressively worsening vision that correlates with structural OCT deterioration over six months; and/or foveal detachment. exclusion criteria * patients with ocular disorders, prior treatments, or other conditions that could affect structural imaging or functional measurements * corneal opacity * uveitis * dense cataract * vitreous haemorrhage * central serous chorioretinopathy * prior retinal laser photocoagulation or photodynamic therapy * previous or concurrent retinal detachment * retinal dystrophies * macular scarring * retinal vascular occlusion * ocular ischaemic syndrome * ungradable OCT/OCTA imaging. * Patients who are cognitively impaired or prisoners are excluded. * Patients considered poor highly myopic surgical candidates are also excluded, including those with myopic choroidal neovascularisation, macular scar, or complete macular atrophy according to the ATN classification. * Participants may also be discontinued from study assessments if OCT imaging is unsatisfactory or ungradable, or if they are unable to complete functional tests such as microperimetry, contrast sensitivity testing, or M-chart assessment.
Where it's running
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Singapore National Eye Centre
Singapore, Singapore, Singapore Recruiting
Study contacts
- Principal investigator: Andrew Tsai, MD — Singapore National Eye Centre
- Study coordinator: Andrew Tsai, MD
- Email: andrew.tsai.s.h@singhealth.com.sg
- Phone: +65 6227 7255
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.